Possible Interaction: Glucose and Indole

“The addition of increasing concentrations of glucose (0 to 110 mM) reduced the formation of both skatole and indole from L-tryptophan and resulted in the accumulation of IAA.”

“ Indole and skatole, as well as tribromethanol, choretone and pentothal, inhibit the uptake of glycine into Ehrlich ascites cells under anaerobic conditions in presence of glucose , the extent of ihibition being greater than the inhibition of anaerobic glycolysis.”

“Starch, d-glucose , salinomycin and monensin inhibited the production of skatole and indole from Trp, and skatole from indoleacetic acid by rumen bacteria.”

“Substitution of glycine for tryptophan 249, whose indole ring interacts with the nonpolar B face of glucose or GlcNAc, greatly increases the K(m) for the acceptor substrate.”

“When 0.02% indole was added, the fungus showed a lag phase for about 30 h and the uptake of glucose was inhibited.”

“2) With a simple salt medium as used by Fildes, glucose only partly inhibits the production of indole (up to about 80 %), but such inhibition can be completed by the additiQn of either phenylalanine or tyrosine in certain stoichiometrical relationships to the tryptophan present.”

“in which the presence of glucose in sufficient amount inhibits completely the production of indole by B. coli, the complete tryptophanase system is absent from the cells. (”