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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“RESULTS: The plasma noradrenaline concentration response to the glucose load was significantly higher after idazoxan than after placebo administration.”
Glucose-induced sympathetic activity and energy expenditure during acute α2-adrenergic antagonism in obese subjects“In vivo, a lower dose of idazoxan was necessary to ameliorate hyperglycaemia induced by the α2-agonist … channel opener, indicating α2A-antagonism as the predominant mechanism of action (decrease in incremental area under the glucose curve induced …/kg idazoxan : under diazoxide, -3±7%, vs. …, -34±9%, P<0.02).”
Dissection of mechanisms that account for imidazoline-induced lowering of blood glucose in mice.“At … mM glucose , there was a moderate but … increase of secretion by idazoxan , 20 µM being nearly as effective as 100 µM. The effect of phentolamine was of slow onset and … in the time frame of the experiments, while the effect of idazoxan was of fast onset and reversible.”
“ Idazoxan in concentrations up to 500 µM was virtually ineffective in the presence of 5 mM glucose.”
“Pretreatment (10 min beforehand) with the beta 2-adrenoceptor antagonist, ICI 118,551 (3 mg/kg) or the alpha 2-adrenoceptor antagonist, idazoxan (1 mg/kg) decreased the rise in levels of glucose in plasma elicited by 2-DG (250 mg/kg).”
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