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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Hydrogen Peroxide
Research Papers that Mention the Interaction
“In fura‐2 loaded INS‐1E cells, a widely used model of β‐cells, and in human β‐cells, H2O2 increased [Ca2+]i, in the presence of 3 mM glucose , by inducing Ca2+ influx across the plasma membrane.”
H2O2-induced Ca2+ influx and its inhibition by N-(p-amylcinnamoyl) anthranilic acid in the β-cells: involvement of TRPM2 channels“Comparable inhibition was observed after treatment of cells with H2O2 delivered either as a bolus or by continuous delivery with glucose and glucose oxidase.”
“ Glucose may oxidise under physiological conditions and lead to the production of protein reactive ketoaldehydes, hydrogen peroxide and highly reactive oxidants.”
“We present evidence that the flux of glucose and sorbitol through the rat lens is markedly reduced by oxidative stress (0.1 mM H2O2).”
“Inhibition of catalase by azide makes the hemoglobin of monkey erythrocytes quite vulnerable to oxidation by hydrogen peroxide even in the presence of added glucose , but rabbit hemoglobin is effectively protected under the same conditions.”
“ Glucose removal causes an increment of H2O2 , an activation of androgen receptor (AR) and a stimulation of AMP-activated protein kinase activity.”
“High glucose induced significant increases in mitochondrial superoxide and hydrogen peroxide (H2O2) at day 1, which remained significantly elevated at days 4 and 7.”
“Through targeting rOHSer to the nucleus, we demonstrated that high levels of D-glucose cause elevated OHP production in this compartment.”
“Co-incubation with glucose and hydrogen peroxide synergistically increased CMV-Hb formation.”
“Likewise, exposure to hydrogen peroxide produced by the action of glucose oxidase on glucose revealed a 4-fold diminished susceptibility of the drug-resistant cells to this reduced form of oxygen.”
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