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“Furthermore, 12-week treatment with HCTZ resulted in significant increases in glucose (+11.0 ± 4.1 mg/dl) and total cholesterol/HDL ratio (+0.3±0.1 mg/dl) and a significant decrease in HDL (–3.2±0.7 mg/dl).”
“After 12 weeks of treatment, oral glucose loading resulted in mean BP reductions of 7 +/- 2 mm Hg (6%, p less than 0.01) and 4 +/- 2 mm Hg (4%, not significant) in the nitrendipine and hydrochlorothiazide groups , respectively.”
Journal of cardiovascular pharmacology • 1988 | View Paper
“IR proved to be metabolically neutral whereas HCT was found to significantly increase the blood levels of triglycerides and glucose by 15.3% (p<0.05) and 12.2% (p<0.05), respectively.”