Possible Interaction: Glucose and Homocysteine

“Results Gaseous sulfur-containing compounds such as methanethiol and hydrogen sulfide were produced when glucose was allowed to react with methionine or its metabolites homocysteine or cysteine.”

“Treatment with HC resulted in concentration-dependent inhibition of insulin secretion induced by glucose and other insulinotropic agents.”

“When cells were exposed to elevated insulin and glucose, homocysteine remethylation was enhanced, which consequently increased intracellular adoMet concentrations by inducing adoMet synthase activity.”

“ Homocysteine was negatively associated with HDL-C (p<0.05) and glucose , although results did not reach significance (p=0.06).”

“CONCLUSION Ho ocysteine lo wers the uptake and utilization of glu cose by down-regulating PDK1 expression and affecting PI3K/Akt signal pathway to cause disturbance of glucose metabolism.”

“Likewise, preincubation with homocysteine caused a reduction in the insulinotropic responses to glucose and each of the secretagogues tested.”

“L-glutamine and L-leucine only increased glucose-stimulated (16.7 mM) insulin secretion (INS-1E cells: 1.5 and 1.3 fold, respectively) at an AA concentration of 20 mM. Homocysteine inhibited insulin secretion both at 5.6 mM and 16.7 mM glucose.”

“This may be due to effects of insulin and/or glucose and/or metabolic control on the metabolism or plasma levels of tHcy.”