Possible Interaction: Glucose and Histidine

“ Histidine had a protective effect on the enzyme inactivation both by glucose plus glucose oxidase and by NaOCI.”

“KEY FINDINGS The addition of increasing concentrations of L- istidine al ong with 10 mM glu cose re sulted in 57% decrease in [Ca(2+)](i).”

“Responses in milk protein yield to combined infusions of His and glucose were additive, suggesting that the utilization of the first-limiting AA His was limited by glucose supply.”

“ LHL strongly ameliorated the severity of renal dysfunction induced by IFO, with significant decreases in total and fractional excretions of Na+, K+, PO43–, and glucose.”

“ Glucose only slightly augmented this effect of L-histidine.”

“When graded levels of L-histidine were added with glucose , histamine concentrations increased accordingly.”

“The absorption of both L-histidine and glucose decreased with time after feeding; the absorption rates for L-histidine and glucose measured for the period 10.00-22-30 hours were 126 and 133%, respectively, of those measured for the period 22.00-22.30 hours.”

“The presence of both D-glucose and L-histidine-binding sites on the same protein with a molecular weight of approximately 55,000 may account for some of the observed competitive inhibitory effects between active intestinal sugar and amino acid transport that have been reported6.”

“The rate of histidase induction by histidine is reduced by incubation of the cells with succinate or glucose.”

“The enhanced pH dependence of the H2O2 cytotoxicity in SFMEM was found to result from the additive action of glucose and histidine present in this medium.”