Possible Interaction: Glucose and Histamine

“Exposure of cells for 5 to 7 days to high (20 mM) external glucose markedly reduced NO production in response to ATP, histamine , or the calcium ionophore calcimycin A23187 compared with 5 and 10 mM glucose concentrations.”

“On the other hand, when histamine was applied to the cells pretreated with 23 mmol/l glucose , it failed to mobilize Ca2+ from both intracellular store sites and extracellular space.”

“In contrast, vasodilatation in response to ADP, acetylcholine, histamine , and NMDA was impaired during application of 20 and 25 mM D-glucose.”

“ Histamine does not interfere with the glucose metabolizing action of insulin, but markedly enhances the utilization of glucose , to judge from a significant decrease in the PAS-positive (hexose) component of histamine-exposed Tetrahymena pyriformis GL cells.”

“After the … of D-glucose, … histamine level in histamine-containing mackerel muscle decreased by 24--65% down from the original amount at temperatures 100--130 degrees C. Further, … technological experiment with the preservation of histamine-containing mackerel muscle was performed, 6% of D-glucose being added to the muscle.”

“Addition of external glucose resulted in a 10-fold increase in lactate formation and this rate was stimulated further by histamine and rotenone.”

“Isoproterenol, nitroprusside, histamine , and bradykinin, when added to 1.5% dextrose dialysate for three consecutive exchanges, all produced approximately a 20% increase in urea and inulin dialysis clearances.”

“ Histamine inhibited incorporation of glucose into this fraction, to a moderate extent.”

“The velocity of ATP-induced histamine release and the final amount of histamine released within 30 min of incubation increased in the presence of glucose.”

“The anaphylactic release of histamine can be prevented by metabolism inhibitors and by anoxia ; the inhibition of metabolism may be counteracted by glucose.”