Possible Interaction: Glucose and Hesperidin

“ Hesperidin attenuated transfer of 14C-labelled glucose across differentiated Caco-2/TC7 cell monolayers.”

“Our results demonstrated that HES decreased the levels of TNF‐α and IL‐6, attenuated the glucose content in culture medium and increased glucose uptake in insulin‐resistant HepG2 cells in vitro.”

“Based on the within-group analysis, hesperidin led to significant decrease in serum levels of glucose , insulin, triglyceride, total cholesterol, low density lipoprotein cholesterol, TNF-α and hs-CRP, while in control group only glucose and insulin significantly decreased.”

“Here, using … μM hesperidin significantly decreased fat accumulation … medium containing 10 mM glucose (83.5 ± 1.2% versus control by Sudan Black B staining and 87.6 ± 2.0% versus control … daf-2 mutant worms (87.8 ± 1.4% versus control by Oil Red O staining; p < 0.001).”

“ Hesperidin treatment significantly reduced the increased intraocular pressure (IOP) level in dextrose induced ocular hypertension than saline treated rats.”

“Treatment with Hesperidin significantly (P<0.05) decreased HbA1c, glucose , CES level and significantly (P<0.01) decreased LDL, TC, TG, systolic and diastolic blood pressure and significant (P<0.01) increased LCAT and LPL level but no significantly change HDL in compared to diabetic control group.”