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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In addition, at 25 mM glucose , enhancement of the oxidative capacity of heparin was also observed.”
“In the presence of heparin all the above alterations, especially at 25 mM glucose , turned out to be antagonized.”
The oxidative mechanism of heparin interferes with radical production by glucose and reduces the degree of glycooxidative modifications on human serum albumin.“Although glucose apparently does not affect alpha1AT functioning, it does enhance the effects of heparin on the alpha1AT structure.”
“ Heparin was observed to bind strongly to alpha1AT, causing maximal enhancement of tryptophan fluorescence emission at 50 microg/ml, mostly in the presence of glucose.”
“Spectroscopic studies showed that the binding sites of glucose and heparin on … that changes in protein structure depend on complex and mutual interference of glucose … heparin with the protein, although the effects of heparin in modifying the chromophore … structure of the protein also prevailed in the presence of glucose.”
“While only a small percentage of albumin molecules underwent fragmentation in the presence of heparin with glucose , albumin turned out to display in an even higher proportion structural modifications consistent with a higher degree of ordered structure.”
“Myocardial net uptakes of glucose , lactate and glutamate and the release of alanine were reduced by heparin in the subjects with normal coronary arteries but not in those with ischemic heart disease.”
“Moreover, the effect of heparin administration suggests that both glucose and heparin compete in vivo for the same functional site.”
“After 5 h in culture, a stimulatory effect of glucose on HR was observed.”
“Moreover, showing the possibility by heparin administration to restore ATIII activity and preserve its biological function from effects of glycemia variations, stress the hypothesis that glucose and heparin compete in vivo, both against the same catalytic residue of ATIII.”
“The enzymatic activity of LPL release from fat tissue by heparin rose significantly one hour after glucose in the normal subjects.”
“A more extensive comparison confirmed a 3-5% loss in heparin activity over 24 hours after dilution in 5% dextrose.”
“ Heparin injected in fasting state slowed significantly the disappearance rate of glucose , but did not change the insulin response.”
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