Possible Interaction: Glucose and Halothane

“Results: Urinary concentrations of aldehydes, acetone, o,o’-dityrosine and glucose were significantly increased after anesthesia in halothane and sevoflurane groups earlier than clinical markers.”

“Splanchnic release of glucose was reduced almost to control values during halothane.”

“The rate of lipid synthesis from glucose was reduced when halothane was present in the gas phase.”

“These results in the human are consistent with the authors' previous findings in the rat, which indicated that halothane may inhibit the uptake or some early step in the utilization of glucose by the myocardium.”

“On the other hand, halothane (greater than or equal to 300 ppm) potently decreased glucose production by hepatocytes.”

“ Halothane , up to 2.4% concentration, had a dose dependent depressant effect on oxygen consumption, mechanical performance, and utilization of media glucose.”

“Although palmitic acid uptake by myocytes was reduced to the same extent by both anesthetics when compared with control uptake values, halothane reduced myocyte uptake of glucose to a greater degree than enflurane.”

“Both halothane and enflurane reduced glucose and palmitic acid metabolism by myocytes when compared with controls.”

“However, after 2 h exposure halothane had decreased glucose production and utilization, as determined with [5-3H]- and [U-14C]-glucose, increased plasma concentrations of insulin and decreased liver concentrations of glycogen, that is it had exacerbated well-known effects of injury in the rat, including insulin resistance.”

“Although the mechanism(s) whereby halothane alters glucose and glycogen metabolism are unknown, it is possible that the anesthetic acts primarily by affecting membranes containing enzymes involved in the metabolism of glycogen.”

“A higher concentration of halothane (8 mM) was required to inhibit CO2 production from glucose in phosphate buffer.”