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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Haloperidol
Research Papers that Mention the Interaction
“Abstract Treatment of rats with D-glucose greatly potentiates the cataleptic response to haloperidol.”
Glucose potentiates haloperidol-induced catalepsy.“In contrast, haloperidol (5μM) was found to cause a marked depolarization of the membrane potential in the presence of both low and high concentrations of glucose.”
Actions of antipsychotic drugs on pancreatic β-cell function: contrasting effects of clozapine and haloperidol“In water controls there were no differences in DA cells per track between rats fed standard chow or chow containing 10% or 20% glucose, whereas these glucose diets significantly attenuated the effects of chronic haloperidol on DA cells per track.”
“The 40% glucose diet itself nonsignificantly reduced cells per track and, in turn, nonsignificantly attenuated the effects of haloperidol.”
“ Glucose also prevents or reverses the increase in discharge rates of dopaminergic cells normally elicited by the antipsychotic agent haloperidol.”
“In contrast, haloperidol led to higher extracellular levels of glucose and lower levels of lactate, suggesting reduced glycolysis.”
Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes
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