Possible Interaction: Glucose and Guar Gum

“We conclude that guar gum attenuates the fall in blood pressure after oral glucose in patients with type 2 diabetes mellitus, presumably by slowing glucose absorption.”

“Results: Treatments containing guar gum had a reduced (P<0.01) baseline-adjusted peak glucose response and incremental area under the glucose curve.”

“The 60 and 120 min areas under the curve for glucose and insulin were significantly reduced by the guar gum meal, as was the 240 min area under the curve for insulin.”

“Addition of guar gum to rolls reduced glucose and insulin responses.”

“The post-treatment (0–120 min) glucose and average appetite were suppressed by alginate and guar gum (p < 0.0001), with more pronounced effect of guar gum.”

“The … the guar gum … glucose drink lowered both postprandial glucose and insulin levels over the following 2 h. This was associated with a reduction in the ratings for … desire to eat and an increase in ratings for fullness and satiety, but energy intake from the test meal was unchanged.”

“ Guar gum eaten with glucose reduced the postprandial hyperglycemia near to the level found after the vegetable meal.”

“Moreover, guar gum markedly increased peripheral glucose clearance, possibly mediated by the SCFA-induced colonic hormone glucagon-like peptide-1.”

“Addition of guar gum to the GD significantly raised gastric pH at 0.5 and 1 h after feeding but, when it was added to HEM, gastric pH was only significantly raised 4 h after feeding.”

“However, addition of guar gum to GD significantly reduced the mean rate of emptying of DM 0.5 h after feeding.”

“ Guar gum significantly reduced the net absorption of glucose from glucose or maltose solutions from 74.2 to 41.4% (P less than 0.001) and 71.1 to 35.0% (P less than 0.001) respectively.”