Possible Interaction: Glucose and Glycine

“When glycine was ingested with glucose , the plasma glucose area response was attenuated by > 50% compared with the response after the ingestion of glucose alone.”

“These observations, taken in conjunction with those from a previous investigation, are consistent with the view that there are two mechanisms for the jejunal absorption of glycine in man, one of which is inhibited by glucose at high intraluminal concentration.”

“To investigate the effect of different intraluminal … on the mutual inhibitive effect of glycine and glucose on their jejunal absorption rates, eighteen convalescent Zambian African patients who had no clinical evidence of intestinal disease or of malnutrition were given constant intrajejunal infusions with those solutes either together or alone.”

“ Glucose breakdown contributes to the formation of the neurotransmitters: acetylcholine, glutamate, aspartate, γaminobutyrate, and glycine.”

“The glucose group had significantly higher concentrations of asparagine, glutamine, glycine , alanine, and lysine after treatment.”

“ Glucose was a positive modulator of the receptor, reducing the average EC50 for glycine up to 4.5‐fold.”

“It should be noted that the glucose plus glycine ORS we used in 1970 [2, 3] significantly improved outcomes despite having the highest osmolality of any ORS yet tested (400 and 510 mOsm/kg), illustrating that substrate absorbability trumps osmolality in patients with cholera and nonvibrio cholera.”

“The amino acids lysine and glycine are reported to react with glucose at physiological pH and temperature and undergo non-enzymic glycation.”

“We present data which indicate that glycine and glucose influence HbA oxygen affinity to the same extent, despite the fact that glycine increases and glucose decreases the bulk dielectric constant of the solution.”

“Indole and skatole, as well as tribromethanol, choretone and pentothal, inhibit the uptake of glycine into Ehrlich ascites cells under anaerobic conditions in presence of glucose , the extent of ihibition being greater than the inhibition of anaerobic glycolysis.”

“It is, however, protected against heat-inactivation by glycine , and this protective effect is intensified in the presence of glucose and inositol.”