Possible Interaction: Glucose and Glutathione Disulfide

“Mixtures of glutathione disulfide and glucose generated two compounds: N-1-Deoxy-fructos-1-yl GSSG (m/z=775 Th) as major adduct and bis di-N, N'-1-Deoxy-fructos-1-yl GSSG (m/z=937 Th) as the minor one.”

“Following addition of glucose , both the oxidized glutathione and the PSSG are rapidly reduced at comparable rates.”

“Glutathione reductase activity from both the control and frozen … a dramatic reduction in substrate specificity (Km) for oxidized glutathione (50%) when measured … presence of glucose (300 mmol l−1) and a increase (157%) when measured in the … levels of urea (75 mmol l−1) encountered in the frozen state.”

“Therefore, a significant increase in the affinity for oxidized glutathione in the presence of endogenous levels of glucose suggests that increased glutathione recycling may occur as a result of passive regulation of glutathione reductase by rising levels of glucose during freezing.”

“In the presence of glucose, oxidized glutathione minimally activated glycogen synthase, and the stimulation by insulin again was reduced with increased oxidized glutathione concentration.”

“In isolated rat pancreatic islets, glucose (5.6,11.1, and 16.7 mM) significantly increased reduced glutathione (GSH) and decreased oxidized glutathione (GSSG) levels in a dose-related manner.”

“The GSSG efflux was inhibited by glucose in the medium.”