Possible Interaction: Glucose and Gluconolactone

“In this work, d-glucono-1,5-lactone was shown to have a much stronger inhibitory effect than d-glucose and d-gluconate on β-glucosidase, a vital enzyme during cellulose degradation.”

“Among various carbon sources, gluconolactone , trehalose, and glycerol enhanced pyrrolnitrin production, whereas strong inhibitory effects were found with glucose.”

“ Glucose and gluconolactone showed competitive inhibition with a Ki of 1 mM and 1.8 μM, respectively, while galactose, mannose, and xylose did not inhibit the enzyme significantly.”

“ D-Glucono-1,5-lactone and glucose are competitive inhibitors while the enzyme was also inhibited by N-bromosuccinimide, N-acetylimidazole, dicyclohexyl carbodiimide, Woodward's Reagent K, 2-hydroxy-5-nitrobenzyl bromide, KMnO4, and some metal ions.”

“ Glucono-delta-lactone and glucose are competitive inhibitors of the enzyme and glucono-delta-lactone is more potent of the two.”

“Both were competitively inhibited by glucose and non-competitively (mixed) inhibited by glucono-1,5-lactone.”

“Inclusion of 100 mM D(+)-gluconic acid-delta-lactone in the incubation mixture inhibited 75% of the glucosidase activity, without inhibiting the synthase activity.”