Possible Interaction: Glucose and Genistein

“ Genistein lowered PEPCK‐C expression and glucose production in HepG2 cells accompanied with increased in phosphorylation states of AMPK, MEK½, ERK½, and CRTC2.”

“A decline in genistein concentration by about 52 and 56% over the 120h culture period was observed with the addition of glucose or FOS to the basal medium (P<0·01), compared with about 91% loss of genistein in the vessels containing Novasoy™ (ADM Neutraceuticals) only.”

“ Genistein — in contrast to daidzein — effectively prevented the glucose mediated LDL oxidation as measured by thiobarbituric acid-reactive substance formation (TBARS), alteration in electrophoretic mobility, lipid hydroperoxides and fluorescence quenching of tryptophan residues of the lipoprotein.”

“In addition the potential of glucose-oxidized LDL to increase tissue factor (TF) synthesis in human endothelial cells (HUVEC) was completely inhibited when genistein was present during LDL oxidative modification by glucose.”

“Systemic treatment of diabetic mice with forskolin or genistein , which bind GLUT1 and inhibit glucose transport, significantly reduced retinal glucose to the same levels seen in non‐diabetics.”

“Similarly to resveratrol, preincubation of adipocytes with genistein slightly reduced ATP in cells exposed to glucose and insulin.”

“Interestingly, these hepatic glucose metabolizing enzyme activities were reversed by the genistein and daidzein supplementation in db/db mice compared to the control group.”

“Leptin secretion stimulated by glucose with insulin was significantly diminished by genistein (0.25--1mM).”

“Collectively, these data suggest that the phytoestrogenic isoflavones daidzein and genistein may reduce glucose toxicity‐induced cardiac mechanical dysfunction and thus possess therapeutic potential against diabetes‐associated cardiac defects.”

“The tyrosine kinase inhibitor genistein reversed the effects of both IL-3 and oncogenes on glucose uptake and reduced transporter affinity for glucose.”

“ Genistein , acting on the adipocytes strongly depressed both basal and insulin-induced lipid synthesis, when glucose was used as a substrate.”