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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Glucose and Flavopiridol



Research Papers that Mention the Interaction

Both flavopiridol and glucose promote the less active T-state through localization of the closed position of the 280s loop which blocks access to the catalytic site, thereby explaining their synergistic inhibition.
The inhibition is synergistic with glucose resulting in a reduction of IC50for flavopiridol to 2.3 μm and mimics the inhibition of caffeine.
The Journal of Biological Chemistry  •  2000  |  View Paper