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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucose
drug:
Epoprostenol
Research Papers that Mention the Interaction
“In experiments in vitro, the increased concentrations of glucose produced dose-dependent inhibition of PGI2 release from isolated rat aortic rings.”
Prostacyclin and blood glucose levels in humans and rabbits.“In contrast, PGI2 release was inhibited in diabetic cells exposed to either 5 or 25 mM D‐glucose.”
“Moreover, decreased local HGF production by high d-glucose was also significantly attenuated by PGI2 analogue or cilostazol.”
“ Glucose (25 mM) stimulated PGI2 secretion by HRPC, but not by either type of endothelial cell, and enhanced PGE2 secretion by HREC, but not by HUVEC or HRPC.”
“These data show for the first time that high concentrations of glucose inhibit PGI2 production by cultured trophoblast cells obtained from early pregnancy.”
“ Prostacyclin at a dose of 10 ng/kg/min raised blood glucose levels both at rest and after stimulation with glucose , and opposed effectively hypoglycemic action of tolbutamide in non-diabetic patients.”
“It was shown that PGI2 production by cultured bovine aortic endothelial cells was significantly reduced in the presence of a high concentration of glucose (300 mg/dl) compared with physiological concentrations of glucose (100 mg/dl).”
Glucose inhibits prostacyclin production by cultured aortic endothelial cells.“Suppression of insulin production in presence of PGI2 in high glucose medium resembles the action of other prostaglandins and suggests it may inhibit insulin secretion after a glucose load.”
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