Possible Interaction: Glucose and Doxorubicin Hydrochloride

“ Doxorubicin reduced the uptake of glucose by retroperitoneal adipocytes and 3T3-L1 cells via the inhibition of AMP-activated protein kinase Thr172 phosphorylation and glucose transporter 4 content.”

“Since the concentration of Glc in diabetic patients is significantly higher than in healthy individuals, the toxic effects of DOX , due to its interaction with Hb, may be different in healthy and diabetic subjects.”

“Furthermore, glucose injections alone reversed the fasting-dependent protection against DXR in mice, indicating that elevated glucose mediates, at least in part, the sensitizing effects of rapamycin and dexamethasone.”

“injections of 2mg/kg DOX demonstrated a shift from the preferential oxidation of fatty acids to enhanced oxidation of glucose and lactate plus pyruvate, indicative of a compensatory shift towards increased pyruvate dehydrogenase activity.”

“The ADM treatment significantly decreased myocardial glycogen and glucose contents , while it did not affect the lactate content.”

“Net efflux of ADR was also observed with the resistant cells, whereas glucose markedly inhibited 2,4-dinitrophenol-stimulated uptake of ADR by the sensitive cells.”

“Parental cells growing in a non-fermentable carbon source medium and mutants lacking mitochondria and grown in glucose medium both show abrupt cell cycle and proliferation arrest during doxorubicin exposure compared to parental cells grown in glucose.”

“For the liver, DOX exposure caused alterations of acetamide, acetic acid, d-glucose , glycerol, l-threonine, palmitic acid, palmitoleic acid, stearic acid, and urea.”

“The IC50 of ADR greatly increased with the increasing concentration of glucose (15±4nM to 93±39nM in HepG2, 78±8nM to 1310±155nM in Bel-7402).”