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Last Updated: 2 years ago

Possible Interaction: Glucose and Doxorubicin Hydrochloride

Research Papers that Mention the Interaction

Doxorubicin reduced the uptake of glucose by retroperitoneal adipocytes and 3T3-L1 cells via the inhibition of AMP-activated protein kinase Thr172 phosphorylation and glucose transporter 4 content.
PloS one  •  2016  |  View Paper
Since the concentration of Glc in diabetic patients is significantly higher than in healthy individuals, the toxic effects of DOX , due to its interaction with Hb, may be different in healthy and diabetic subjects.
International journal of biological macromolecules  •  2021  |  View Paper
Furthermore, glucose injections alone reversed the fasting-dependent protection against DXR in mice, indicating that elevated glucose mediates, at least in part, the sensitizing effects of rapamycin and dexamethasone.
PLoS biology  •  2017  |  View Paper
injections of 2mg/kg DOX demonstrated a shift from the preferential oxidation of fatty acids to enhanced oxidation of glucose and lactate plus pyruvate, indicative of a compensatory shift towards increased pyruvate dehydrogenase activity.
Toxicology  •  2010  |  View Paper
The ADM treatment significantly decreased myocardial glycogen and glucose contents , while it did not affect the lactate content.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1982  |  View Paper
Net efflux of ADR was also observed with the resistant cells, whereas glucose markedly inhibited 2,4-dinitrophenol-stimulated uptake of ADR by the sensitive cells.
Cancer research  •  1979  |  View Paper
Parental cells growing in a non-fermentable carbon source medium and mutants lacking mitochondria and grown in glucose medium both show abrupt cell cycle and proliferation arrest during doxorubicin exposure compared to parental cells grown in glucose.
Cell cycle  •  2021  |  View Paper
For the liver, DOX exposure caused alterations of acetamide, acetic acid, d-glucose , glycerol, l-threonine, palmitic acid, palmitoleic acid, stearic acid, and urea.
ACS omega  •  2021  |  View Paper
The IC50 of ADR greatly increased with the increasing concentration of glucose (15±4nM to 93±39nM in HepG2, 78±8nM to 1310±155nM in Bel-7402).
Endocrine-related cancer  •  2018  |  View Paper