Possible Interaction: Glucose and Desoxycorticosterone Acetate

“The paradoxical hyperkalemic response to glucose in patients with combined hormonal deficiency was blunted by prior administration of desoxycorticosterone acetate and abolished by prior administration of insulin.”

“Although DOCA replacement modifies the distribution of potassium in the extracellular fluid and blunts the hyperkalemic effect of intravenous infusions of glucose , a rise in the insulin level is required for the usual hypokalemic response to intravenously administered glucose.”

“It is suggested that DOCA may have a direct or indirect action on the assimilation, production, or utilization of glucose , perhaps leading to an improvement in insulin sensitivity and subsequently a decrease in insulin secretion.”

“Daily administration of DOCA for short periods caused an increased glycogenic response in liver of rats following intraperitoneal injection of glucose.”