Possible Interaction: Glucose and Deoxycholate

“Chemical modification (by 2.5 mmol/L sodium deoxycholate ) increased glucose and icodextrin I-->M transfer a mean of 41% and 81% respectively, but increased M-->I transfer by 70% and 224% respectively.”

“At pH 7.4, 1 mM deoxycholate inhibited the respiration by 49% and the rates of oxidation by 51%, 52%, 78%, 74%, and 54% of control values, for glucose , pyruvate, succinate, acetate, and butyrate, respectively.”

“ Deoxycholate at 8 microM in the blood supply of the perfused jejunal segment was associated with a significant (p less than 0.02) reduction in the absorption rates of water, sodium, glucose , and glycine, and inhibition of mucosal Na+, K+-ATPase.”

“The dialysate-plasma dextrose gradient dissipated faster with 10 mg/kg of desoxycholate.”

“Similarly, 5 mM deoxycholate enhanced jejunal absorption of mannitol (p less than 0.01) and reduced the absorption of glucose and the low-molecular-weight ethylene glycols (p less than 0.01).”