Possible Interaction: Glucose and Conjugated Linoleic Acid

“In conclusion, CLA when consumed during gestation and lactation increased: tolerance to glucose , HDL, and the body fat index in the offspring.”

“Serum NEFA levels in response to oral glucose were attenuated in both men and women in the CLA (P=0.001) compared to control group.”

“Moreover, although livers were chemically and histologically normal, pigs fed CLA diet challenged with a glucose load had higher serum glucose than controls.”

“In addition, CLA decreases hepatic glucose production through decreased gluconeogenesis.”

“Some major factors affecting the ruminal environment such as diet, concentrations of fat substrates, incubation time, pre-incubation, and the presence of glucose in the medium were found to be important determinants for the ruminal production of CLA and in a close relationship with biohydrogenation.”

“ CLA (50-200muM) decreased basal glucose uptake (P<0.05-0.01) and significantly increased the proportion of glucose metabolized to lactate (P<0.01).”

“These results indicate that CLA inhibits leptin and adiponectin secretion and suggest that increased anaerobic metabolism of glucose may be involved in these effects.”

“Serum levels of glucose , insulin, the pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), as well as insulin resistance index (IRI), decreased with CLA , whereas CLA and Cr in combination had significant effects on insulin and IL-6 concentrations and IRI.”