Possible Interaction: Glucose and Colforsin

“ Forskolin mimicked the repression of Cx36 by glucose.”

“The addition of phorbol-12-myristate-13-acetate, dibutyryl cyclic AMP, and forskolin increased luciferase expression in the presence of either 1 mM or 25 mM glucose.”

“Agents that increase cAMP levels, including forskolin plus 3-isobutyl-1-methylxanthine (fsk/IBMX), triggered a rise in the intracellular calcium concentration and enhanced the response to glucose by increasing both the number of cells responding to glucose and the magnitude of calcium responses in individual cells.”

“An increase from 1 to 15 mmol/l glucose induced biphasic insulin secretion with a prominent first phase (peak increase of ∼18-fold) and a sustained, flat second phase (∼10-fold increase), which were both potentiated by forskolin.”

“ Forskolin labeling of this region was inhibited by cytochalasin B and D-glucose , but not L-glucose.”

“However, with both nifedipine and diazoxide, glucose induced a 5-fold increase in insulin release in the presence of 10 μM forskolin , an activator of adenylyl cyclase.”

“Insulinotropic action of 6.7 mmol/l glucose with forskolin was also deteriorated in diabetic islets.”

“Systemic treatment of diabetic mice with forskolin or genistein, which bind GLUT1 and inhibit glucose transport, significantly reduced retinal glucose to the same levels seen in non‐diabetics.”

“GLUT1 inhibitors Hg(II), cytochalasin B and forskolin reduced uptake of glucose but not CH₃As(OH)₂. These results indicate that CH₃As(OH)₂ and water use a common translocation pathway in GLUT1 that is different to that of glucose transport.”

“In contrast, when glucose or tolbutamide were added together with forskolin secretion was potentiated five- to tenfold.”