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Last Updated: 4 months ago

Possible Interaction: Glucose and Colforsin



Research Papers that Mention the Interaction

Agents that increase cAMP levels, including forskolin plus 3-isobutyl-1-methylxanthine (fsk/IBMX), triggered a rise in the intracellular calcium concentration and enhanced the response to glucose by increasing both the number of cells responding to glucose and the magnitude of calcium responses in individual cells.
Diabetologia  •  2007  |  View Paper
An increase from 1 to 15 mmol/l glucose induced biphasic insulin secretion with a prominent first phase (peak increase of approximately 18-fold) and a sustained, flat second phase ( approximately 10-fold increase), which were both potentiated by forskolin.
Diabetes  •  2006  |  View Paper
The stimulatory effects of palmitate and forskolin at 12 mM glucose were also significantly higher in pseudoislets than in islets.
Scientific Reports  •  2019  |  View Paper
AC activity, intracellular cAMP levels, and glucose release from isolated hepatocytes were significantly enhanced by NaF, forskolin , epinephrine, and phenylephrine.
American journal of physiology. Regulatory, integrative and comparative physiology  •  1998  |  View Paper
Restimulation of glucose-desensitized islets with 20 mM glucose plus 500 nM forskolin resulted in a dramatic enhancement of both phases of secretion.
American journal of physiology. Endocrinology and metabolism  •  1998  |  View Paper
Forskolin mimicked the repression of Cx36 by glucose.
Journal of cell science  •  2005  |  View Paper
The addition of phorbol-12-myristate-13-acetate, dibutyryl cyclic AMP, and forskolin increased luciferase expression in the presence of either 1 mM or 25 mM glucose.
Pharmaceutical Research  •  2002  |  View Paper
Moreover, 72 h culture in the presence of 30 mmol/L glucose reduced forskolin-stimulated cAMP accumulation in β-cells.
Journal of diabetes  •  2015  |  View Paper
However, with both nifedipine and diazoxide, glucose induced a 5-fold increase in insulin release in the presence of 10 μM forskolin , an activator of adenylyl cyclase.
Endocrine journal  •  2013  |  View Paper
Insulinotropic action of 6.7 mmol/l glucose with forskolin was also deteriorated in diabetic islets.
Physiological research  •  2013  |  View Paper
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