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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glucose
drug:
Cilostazol
Research Papers that Mention the Interaction
“ Cilostazol inhibited the proliferation of human VSMCs in response to high glucose in vitro and virtually abolished neointimal formation in rats subjected to carotid artery injury in vivo.”
Cilostazol Inhibits Vascular Smooth Muscle Cell Growth by Downregulation of the Transcription Factor E2F“ Cilostazol also significantly recovered reduced levels of protein kinase A activity (PKA) in 50 mM glucose.”
“In cells grown in 50 mM glucose, cilostazol was observed to increase significantly both NO production and cellular cAMP accumulation in a time- and dose-dependent manner.”
“However, the decrease in local HGF production by high d-glucose was significantly attenuated by addition of PGI2 analogue or cilostazol.”
“Moreover, decreased local HGF production by high d-glucose was also significantly attenuated by PGI2 analogue or cilostazol.”
“Overall, this study demonstrated that treatment with PGE, PGI2 analogue or cilostazol prevented aortic EC death induced by high d-glucose , probably through the activation of local HGF production.”
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