Possible Interaction: Glucose and Canagliflozin

“ Canagliflozin administration increased urinary glucose excretion, which was sustained during repeated-dose administration.”

“… canagliflozin significantly decreased adiposity … levels of fasting glucose and HbA1c but increased average serum FABP4 level by 10.3% (18.0 ± 1.0 vs. 19.8 ± 1.2 ng/…, P = 0.008), though elevation of FABP4 level after treatment was observed in 26 (66.7%) out of 39 patients.”

“ Canagliflozin decreased the 24-hour mean renal threshold for glucose and increased urinary glucose excretion in a dose-dependent manner; these results are consistent with those observed in other patient populations.”

“ Canagliflozin … glucose , calculated by using measured creatinine clearance to estimate the glomerular filtration rate (67.9 and 60.7 mg/dL for canagliflozin 100 and 300 ….9 g for canagliflozin 100 and 300 mg, respectively) in a dose-dependent manner; the 24-hour plasma glucose profile remained largely unchanged.”

“ResultsIn Studies 1 and 2, both canagliflozin doses increased beta cell glucose sensitivity compared with placebo.”

“Results: The changes in HbA1c (−0.74 and −0.76 vs + ….7 mg/dl), 2-h plasma glucose after 75-g glucose load (−84.9 and −79.0 vs −0.5 mg/dl), body weight (percent … vs −2.72 mmHg) were significantly greater with 100 and 200 mg canagliflozin …).”

“ Canagliflozin , a selective sodium/glucose cotransporter (SGLT) 2 inhibitor, suppresses the renal reabsorption of glucose and decreases blood glucose level in patients with type 2 diabetes.”

“ Canagliflozin , the first sodium-glucose cotransporter 2 inhibitor presently available on the market, offers a unique mechanism of action: it inhibits renal reabsorption of glucose , thereby increasing urinary glucose excretion.”

“In particular, canagliflozin blocks the re-absorption of glucose in the kidney lowering blood glucose levels by increasing glucose excretion.”

“ Canagliflozin , an SGLT2 inhibitor, lowers the renal threshold for glucose and increases urinary glucose excretion leading to a mild osmotic diuresis and a net caloric loss.”

“ Canagliflozin decreased the renal threshold for glucose (RTG) and increased the urinary glucose excretion (UGE) in a concentration- and dose-dependent manner.”