Possible Interaction: Glucose and Alpha-lipoic acid

“In addition, alpha-lipoic acid seems to inhibit hepatic gluconeogenesis by interfering with fatty acid oxidation, as well as to increase peripheral glucose utilization by activating pyruvate dehydrogenase resulting in increased glucose oxidation.”

“This finding provides a possible mechanism for a glucose (and lactate) lowering effect of R-lipoic acid in diabetic subjects.”

“Furthermore, both qualitative and quantitative investigations of insulin secretion have shown that ALA can improve aged cells’ function and increase insulin secretion specially in the stimulating concentration of glucose.”

“Furthermore, ALA significantly upregulated the glycolytic enzymes GCK, HK-1 and PK, and the glycogen synthesis enzyme GS, and downregulated the gluconeogenic enzymes PEPCK and G6Pase, thus decreased glucose production , and promoted glycogen synthesis and glucose utilization in livers.”

“Moreover, LA stimulated the anaerobic utilization of glucose to lactate , which negatively correlated with leptin secretion.”

“The simultaneous treatment with lipoic acid also attenuated the rise in insulin levels as well as in insulin resistance in the glucose fed rats.”

“The addition of alpha-lipoic acid partially prevented the glucose and L-fucose-induced activation of NF-kappaB, generation of reactive oxygen species, and increase in monocyte adhesion.”

“Also at low lactate concentrations (1 mmol L(-1)), 10(-3) mol L(-1) RLA reduced glucose production by approximately 53% and lactate uptake by approximately 60%, but stimulated bile secretion by approximately 50% (P < 0.05).”

“Aim: Alpha‐lipoic acid has been reported to increase glucose disposal in diabetic states.”

“Lipoic acid LA ) is a unique antioxidant that increases peripheral glucose utilization in diabetic patients.”

“This study was conducted to investigate whether the inhibition of glucose production could be an additional mechanism for the action of LA.”