Possible Interaction: Glucose and Alpha-Ketoglutaric Acid

“1-4 In psychotic subjects the administration of glucose is frequently followed by excessive or prolonged elevations of blood levels of glucose, lactate pyruvate, citrate, and α-ketoglutarate in psychotic subjects.”

“Incubation with 10 mM α-ketoglutarate or L-glutamate led to enhanced glucose production and an increase in tissue content of NAD + .”

“Lactate, pyruvate, oxalacetate, and succinate are very effective in producing respiratory stimulation and affording a Crabtree effect, but malate, citrate, and α-ketoglutarate produce very little respiratory stimulation and very little inhibition when glucose also is added.”

“When growing with glucose , the acetyl-CoA concentration, alpha-ketoglutaric acid , and the value of C(alpha-KG)/Cpyr were 222%, 105% and 152% higher than those of the parent strain WSH-IP303, respectively.”

“In addition, both thiosulfate and glucose inhibit the synthesis of the Krebs cycle enzymes, nicotinamide adenine dinucleotide phosphate-linked isocitrate and α-ketoglutarate dehydrogenases.”

“The addition of glutamate, α-ketoglutarate , or compounds capable of being catabolized to glutamate, to a minimal glucose medium resulted in complete repression of aconitase in B. subtilis and B. licheniformis.”