Possible Interaction: Glucose and Adrenocorticotropic Hormone

“ ACTH leads to an increased frequency of yawning and headshaking and glucose to a decrease in arousal.”

“Recently, it has been demonstrated that morning glucose ingestion stimulates pulsatile cortisol and adrenocorticotropic hormone (ACTH) secretion, thus elevating their mean concentrations.”

“Independent of sleep, glucose infusion reduced levels of ACTH (P<0.01) and cortisol (P<0.02) during the second night half.”

“Furthermore, cortisol and ACTH levels increased paradoxically in patients after glucose ; this was more pronounced in patients with long CTG repeat expansions.”

“The effect of corticotropin was inhibited by glucose and insulin, presumably due to promotion of esterification of the free acids.”

“ ACTH induced an elevation in cortisol, aldosterone, glucose , and fatty acids within 2 h, with complete recovery observed within 24 h of administration.”

“Further, ACTH resulted in increases (P < 0.01) glucose , insulin, and leptin concentrations.”

“Continuous delivery of ACTH at 8 IU/kg BW/d for 7 d caused increases in plasma corticosterone (CS), glucose ( GLU ), cholesterol (CHOL), triglycerides (TRI), high-density lipoprotein (HDL), total protein (TP), and the heterophil/lymphocyte (H/L) ratio.”

“Increments in ACTH (rs = -0.96, P < 0.005) and CRH (rs = -0.81, P < 0.05), but not in AVP, measured during the second half-hour after insulin (i.e. the peak response), were inversely ranked with the glucose nadir.”

“ ACTH significantly enhanced the release of insulin elicited by either 3.3 or 16.6 mM glucose.”