Possible Interaction: Glucose and Acipimox

“ Acipimox reduced plasma free fatty acids (FFA) markedly and lowered plasma triglycerides, glucose and insulin.”

“Areas under the glucose and insulin curves during oral glucose tolerance testing were both approximately 30% lower after Acipimox administration than after placebo.”

“The short-term administration of a nicotinic acid analogue acipimox ) increases insulin sensitivity and consequently glucose disposal , both in patients with non-insulin-dependent diabetes mellitus (NIDDM) and in patients with cirrhosis.”

“ Acipimox blunted the … in glucose after oral glucose loading and decreased incremental glucose concentration (from 579 +/- 76 to 445 +/- 65 mmol/min/L, P less than .02) and incremental insulin concentration (from 13.4 +/- 2.5 to 9.0 +/- 1.4 U/min/L, P = .056) in the OGTT.”

“ Acipimox tended to increase glucose and decrease lipid utilization rates at the whole body level and significantly changed the effect of insulin on substrate utilization.”

“RESULTS Ba al glucose tu rnover was significantly reduced by addition of aci pimox (r ate of disappearance (Rd) glucose (mg/kg/min): 1.91+/-0.08 (expt.”

“Similar to CL-316243, Acipimox (150 mg/kg orally) markedly decreased plasma FFA, glucose , and insulin concentrations and improved glucose tolerance while reducing the insulin response in obese (350 to 400 g) ZDF rats.”