Possible Interaction: Glucosamine and Uridine

“A 50% decrease in growth also persisted when uridine and cytidine, cytidine alone, or UDP, were added together with D-glucosamine.”

“For [3H]glucosamine , pretreatment with uridine resulted in a reduction of the glycosylation in both fractions.”

“Furthermore the complete resumption of the capacity to incorporate either 3H-thymidine or 3H-mannose which was observed after the removal of the aminosugar, was impeded when the cells were treated contemporaneously with D-glucosamine and uridine.”

“Abstract As a consequence of the reduction of the UTP pool by glucosamine the velocity of the uptake of uridine into the cells is drastically increased.”

“The 100 μmoles/ml of d -glucosamine caused the following decreases in μmoles of uridine nucleotides per 10 11 cells: UMP 66 to 28, UDP 55 to 31, and UTP 49 to 28 while increasing the UDP- N -acetylhexosamine pool from 48 to 102 μmoles per 10 11 cells.”

“ D-Glucosamine inhibited the incorporation of labeled uridine and amino acids into acid-precipitable material.”

“Abstract When cultured Drosophila cells are pretreated with glucosamine and exposed to a pulse of incorporation of radioactive uridine , their labeling can be halted almost instantaneously by the addition of unlabeled uridine.”