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Discover Supplement-Drug Interactions

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Possible Interaction: Glucosamine and Salicylic Acid

Research Papers that Mention the Interaction

Significant increases in the excretion rate of sodium salicylate were observed upon the addition of an equal amount of glucosamine hydrochloride to an orally administered solution dosage form.
Journal of pharmaceutical sciences  •  1965  |  View Paper
Analysis of the papain-digested glycoprotein from tissue incubations …-d-[2-(14)C]glucose in the presence of salicylate (3.75mm) showed large decreases in labelling of N-acetylneuraminic acid and N-… residues (57% and 34% of the control values respectively) and of hexosamine constituents ( glucosamine , 55% inhibition; …% inhibition).
The Biochemical journal  •  1968  |  View Paper
Salicylate therefore inhibits the incorporation of glucosamine which occurs independently of protein synthesis, and thus appears to have a specific inhibitory effect on oligosaccharide assembly.
Sodium salicylate at concentrations of 7.5 mM and 15.0 mM inhibited incorporation of [I- 14 C]glucosamine into glycoprotein by slices of rat small intestine.
Biochimica et biophysica acta  •  1972  |  View Paper