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Possible Interaction: Glucosamine and Nitric Oxide

supplement:

Glucosamine

Research Papers that Mention the Interaction

Glucosamine hydrochloride at a concentration of 100 microg/ml suppressed PGE2 production, and partly suppressed NO production.
Clinical and experimental rheumatology  •  2004  |  View Paper
Pretreatment with 2 mg/mL GH also reduced the release of inflammatory markers, prostaglandin E2 and nitric oxide induced by IL-1α while CS did not have a significant effect.
Cartilage  •  2016  |  View Paper
The addition of 25 mg/ml of glucosamine prevented the increase in nitric oxide production, proteoglycan release and MMP activity induced by LPS or rhIL-1.
Osteoarthritis and cartilage  •  2000  |  View Paper
Using the rat alveolar epithelial cell line L2, we noted that the cytokine mixture (cytomix)-regulated production and mRNA expression of CINC-1 and MIP-2, NO production, the protein and mRNA expression of iNOS, iNOS mRNA stability, and iNOS promoter activity were all inhibited by glucosamine.
American journal of respiratory cell and molecular biology  •  2013  |  View Paper
Nucleus cells, 7 days: Glucosamine reduced IL-6 (by 89%), PGE(2) (91%), and NO (90%) with no effect to viability.
RESULTS Annulus cells, 7 days: Glucosamine completely inhibited IL-6 and TNF-alpha, increased NO (by 75%), and reduced viability (by 89%) compared with IL-1 alone.
The spine journal : official journal of the North American Spine Society  •  2007  |  View Paper
These results indicate that GLN suppresses the LPS-induced production of NO , expression of iNOS and COX-2 by inhibiting NF-kappaB activation and phosphorylation of p38 MAP kinase.
Treatment with GLN inhibited LPS-stimulated nitric oxide ( NO ) production.
Molecular nutrition & food research  •  2007  |  View Paper
CONCLUSION Our results indicate that physiologically relevant concentrations of GLN and CS can regulate gene expression and synthesis of NO and PGE(2), providing a plausible explanation for their purported anti-inflammatory properties.
CONCLUSION Our results indicate that physiologically relevant concentrations of GLN and CS can regulate gene expression and synthesis of NO and PGE(2), providing a plausible explanation for their purported anti-inflammatory properties.
Osteoarthritis and cartilage  •  2005  |  View Paper
Glucosamine and mannosamine at concentrations as low as 0.5 mg/mL inhibited NO production.
American journal of veterinary research  •  2004  |  View Paper
Furthermore, glucosamine reduced the production of nitric oxide and prostaglandin E2 in plasma (p < 0.05).Conclusions: These observations suggest that glucosamine is able to suppress the progression of adjuvant arthritis in rats.
Inflammation Research  •  2004  |  View Paper
Based on recent findings that excess production of nitric oxide (NO) by inducible NO synthase (iNOS) mediates the pathogenesis of arthritis, we hypothesized that glucosamine may inhibit NO synthesis.
These studies demonstrate that glucosamine is a novel inhibitor of inducible NO synthesis via inhibition of iNOS protein expression, and provide a biochemical basis for the use of glucosamine in treating chronic inflammatory diseases such as arthritis.
When cultured macrophages were treated with LPS (1 microg/ml) to induce iNOS expression, addition of 0.1, 0.5, 1, and 2 mM d-glucosamine decreased NO production by 18, 38, 60, and 89%, respectively.
Biochemical and biophysical research communications  •  2000  |  View Paper