Possible Interaction: Glucosamine and Mannose

“On the other hand, 2 mm glucosamine in the culture medium increased UDP-HexNAc content, stimulated hyaluronan secretion, and negated the effect of mannose , supporting the notion that the inhibition by mannose on hyaluronan synthesis was because of down-regulated UDP-HexNAc content.”

“With respect to the glycosylation of sugar precursors, the incorporation of mannose is more inhibited than that of glucosamine , while fucose is least impacted.”

“Galactosamine and trehalosamine were inactive in this system, whereas glucosamine also inhibited mannose incorporation into GPI intermediates.”

“In its presence, the incorporation of glucosamine was inhibited 70% and mannose , 96% compared to controls.”

“D‐Glucose, D‐mannose , 2‐deoxy‐D‐glucose and 3‐0‐methyl‐o‐glucose are potent inhibitors of D‐glucosamine uptake.”

“A 10‐fold reduction in the concentration of glucosamine (0.55 mM) allows for the escape from repression of mannose , glucose, and deoxyglucose uptake while the others remain repressed.”