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Possible Interaction: Glucosamine and Leptin

supplement:

Glucosamine

drug:

Leptin

Research Papers that Mention the Interaction

Glucosamine treatment, which bypasses the rate-limiting step in the synthesis of substrate for glycosylation, increased both O-GlcNAc and leptin , whereas inhibition of O-glycosyltransferase (OGT) decreased O-GlcNAc and leptin.
The Journal of biological chemistry  •  2019  |  View Paper
In addition, the level of the transcripts encoding signal transducer and activator of transcription-3 and -5, both implicated in leptin signal transduction in islet β-cells, was increased by glucosamine , although to a lesser degree than mRNA levels of leptin and OB-Rb.
In the present study we found that glucosamine rapidly activates the production of leptin and OB-Rb, which encodes the functional leptin receptor, in both primary pancreatic islets and clonal β-cells.
In these tissues leptin gene expression is increased by glucosamine.
Endocrinology  •  2001  |  View Paper
Glucosamine (1 mM), an intermediate in hexosamine biosynthesis, increased leptin release to 117.0 +/- 7.3% (P = 0.0430; n = 9) and 134.6 +/- 6.5% of the control value (P = 0.0367; n = 4) by 48 and 96 h, respectively.
Glucosamine (1 mM; 48 h) also increased LEP promoter activity 170.0 +/- 13.0% (n = 5).
With 0.01 mM glucosamine, leptin release was increased to 120.0 +/- 3.0% of the control value (P = 0.0069; n = 4) by 96 h of treatment.
Endocrinology  •  2002  |  View Paper
Furthermore, glucose-free Lab-D supplemented with 1 mM glucosamine , an intermediate product in UDP-N-acetylglucosamine biosynthesis, increased leptin secretion by 28+/-11% over control (P<0.05), although without effect on leptin mRNA, after 48 h of culture.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association  •  2005  |  View Paper
In addition, the level of the transcripts encoding signal transducer and activator of transcription-3 and -5, both implicated in leptin signal transduction in islet beta-cells, was increased by glucosamine , although to a lesser degree than mRNA levels of leptin and OB-Rb.
In the present study we found that glucosamine rapidly activates the production of leptin and OB-Rb, which encodes the functional leptin receptor, in both primary pancreatic islets and clonal beta-cells.
In these tissues leptin gene expression is increased by glucosamine.
Endocrinology  •  2001  |  View Paper