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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucosamine
drug:
Leptin
Research Papers that Mention the Interaction
“ Glucosamine (1 mM), an intermediate in hexosamine biosynthesis, increased leptin release to 117.0 +/- 7.3% (P = 0.0430; n = 9) and 134.6 +/- 6.5% of the control value (P = 0.0367; n = 4) by 48 and 96 h, respectively.”
“ Glucosamine (1 mM; 48 h) also increased LEP promoter activity 170.0 +/- 13.0% (n = 5).”
“With 0.01 mM glucosamine, leptin release was increased to 120.0 +/- 3.0% of the control value (P = 0.0069; n = 4) by 96 h of treatment.”
Hexosamines regulate leptin production in 3T3-L1 adipocytes through transcriptional mechanisms.“Treatment … glucosamine , an … leptin release 21.4+/-17.6% (mean +/- SD) over control (P = 0.0365) and 74.5+/-82.8% over control (P = 0.0271) in … kg/m2; n = 6) and obese (BMI, 55.4+/-13.0 kg/m2,; n = 9) subjects, respectively, by 48 h of culture.”
“Furthermore, glucose-free Lab-D supplemented with 1 mM glucosamine , an intermediate product in UDP-N-acetylglucosamine biosynthesis, increased leptin secretion by 28+/-11% over control (P<0.05), although without effect on leptin mRNA, after 48 h of culture.”
Glucose-containing peritoneal dialysis fluids regulate leptin secretion from 3T3-L1 adipocytes.“In addition, the level of the transcripts encoding signal transducer and activator of transcription-3 and -5, both implicated in leptin signal transduction in islet beta-cells, was increased by glucosamine , although to a lesser degree than mRNA levels of leptin and OB-Rb.”
“In the present study we found that glucosamine rapidly activates the production of leptin and OB-Rb, which encodes the functional leptin receptor, in both primary pancreatic islets and clonal beta-cells.”
“In these tissues leptin gene expression is increased by glucosamine.”
“In addition, the level of the transcripts encoding signal transducer and activator of transcription-3 and -5, both implicated in leptin signal transduction in islet β-cells, was increased by glucosamine , although to a lesser degree than mRNA levels of leptin and OB-Rb.”
“In the present study we found that glucosamine rapidly activates the production of leptin and OB-Rb, which encodes the functional leptin receptor, in both primary pancreatic islets and clonal β-cells.”
“In these tissues leptin gene expression is increased by glucosamine.”
Hexosamines and Nutrient Excess Induce Leptin Production and Leptin Receptor Activation in Pancreatic Islets and Clonalβ -Cells.
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