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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Glucosamine
drug:
Interferons
Research Papers that Mention the Interaction
“At 80 mM d -glucosamine or at 8 mM 2-deoxy- d -glucose, interferon production was inhibited by approximately 95%; however, at 20 and 2 mM, respectively, these inhibitors allowed interferon production at about 50% of levels produced by leukocytes not treated with the inhibitors.”
Effect of glycosylation inhibitors on the production and properties of human leukocyte interferon.“ Interferon production was inhibited in the Namalwa line of human lymphoblastoid cells by treatment with 2-deoxy-D-glucose or D-glucosamine.”
“ Interferon synthesized in the presence of partially inhibitory concentrations of 2-deoxy-D-glucose or D-glucosamine were found to differ from interferons made in control cultures in some physical properties.”
“Residual active interferon made in the presence of d -glucosamine was less efficiently neutralized by anti-interferon antibody than control interferon.”
“Galactose (±uridine), glucosamine (±uridine), and N‐acetylmannosamine (ManNAc) (±cytidine) feeding resulted in 12%, 28%, and 32% increase in IFN‐γ sialylation as compared to the untreated control cultures.”
An investigation of intracellular glycosylation activities in CHO cells: Effects of nucleotide sugar precursor feeding“The present data show that GlcN , but not GlcNAc, inhibits CD4+ T‐cell proliferation, the generation of alloreactive cytotoxic T lymphocytes (CTLs) and the secretion of interferon‐γ (IFN‐γ) and interleukin‐5 (IL‐5) in primary MLC.”
“Glycosylation inhibitors like glucosamine were uneffective on interferon induction 'in vivo'.”
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