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Last Updated: 15 days ago

Possible Interaction: Glucosamine and Insulin

supplement:

Glucosamine

drug:

Insulin

Research Papers that Mention the Interaction

Additional in vitro experimental support for the glucosamine hypothesis comes from findings indicating that GlcN induces insulin resistance in isolated rat muscle (23) and may modulate insulin’s and/or glucose’s effects on pyruvate kinase (24), glycogen synthase (23, 25) and transforming growth factor-a (26).
GlcN infusion has also been reported to influence insulin sensitivity not only in skeletal muscle and adipose tissue but also in heart muscle and liver (31).
European journal of endocrinology  •  1998  |  View Paper
An overnight exposure to glucosamine markedly attenuated the effects of insulin and IGF-I in stimulating glycogen synthesis.
Exposure to glucosamine also resulted in a reduction in the ability of IGF-I or insulin to stimulate phosphorylation of insulin IGF-I/HRs.
Taken together, … indicate that glucosamine induces a loss … to stimulation of insulin , IGF-I, or HR tyrosine kinase activity by insulin or IGF-I. Although insulin is able to partially reverse … of glucosamine on IR phosphorylation, it has a very minimal effect on glucosamine-induced inhibition of HR phosphorylation.
The combination of insulin plus IGF-I was a more potent stimulus of HR phosphorylation than either agent alone, and this combination was also more potent in partially reversing the inhibitory effect of glucosamine.
Endocrinology  •  2003  |  View Paper
Insulin hastened the disappearance of glucosamine from the plasma of the alligator.
The American journal of physiology  •  1962  |  View Paper
Overall, the findings support a model whereby GAM promotes ER stress in retinal Müller cells, resulting in elevated REDD1 expression and thus resistance to insulin action.
Cellular signalling  •  2016  |  View Paper
For instance, whereas in one study, short-term glucosamine did not influence insulin sensitivity in humans, another study demonstrated that long-term glucosamine treatment does attenuate insulin release.
Menopause  •  2012  |  View Paper
…,insulin stimulated-glucose transport was significantly increased and continued to increase up to 6-24 h. Insulin stimulation of Akt, however, did not increase after … increase after 6 h. Next, we investigated effects of osmotic shock and vanadate on glucose transport in glucosamine-treated cells and found that glucosamine ….
Biochemical and biophysical research communications  •  2002  |  View Paper
When we measured the kinase activity of protein kinase C (PKC) lamda, which is the downstream effector of PI 3-kinase in isolated adipocytes, we found that glucosamine inhibited insulin stimulated PKClamda kinase activity by 33%.
The Kobe journal of medical sciences  •  2002  |  View Paper
However, only preincubation with GlcN plus insulin inhibited insulin-stimulated GLUT4 translocation.
Diabetes  •  2000  |  View Paper
GlcN inhibits insulin action on both PKA and CK-1 activities.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research  •  2000  |  View Paper
Surprisingly, glycogen synthase activation by insulin was enhanced 4-fold, in part due to allosteric activation by a glucosamine metabolite.
The Journal of Biological Chemistry  •  1999  |  View Paper
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