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Possible Interaction: Glucosamine and Insulin

supplement:

Glucosamine

drug:

Insulin

Research Papers that Mention the Interaction

An overnight exposure to glucosamine markedly attenuated the effects of insulin and IGF-I in stimulating glycogen synthesis.
Exposure to glucosamine also resulted in a reduction in the ability of IGF-I or insulin to stimulate phosphorylation of insulin IGF-I/HRs.
Taken together, … indicate that glucosamine induces a loss … to stimulation of insulin , IGF-I, or HR tyrosine kinase activity by insulin or IGF-I. Although insulin is able to partially reverse … of glucosamine on IR phosphorylation, it has a very minimal effect on glucosamine-induced inhibition of HR phosphorylation.
The combination of insulin plus IGF-I was a more potent stimulus of HR phosphorylation than either agent alone, and this combination was also more potent in partially reversing the inhibitory effect of glucosamine.
Endocrinology  •  2003  |  View Paper
Insulin hastened the disappearance of glucosamine from the plasma of the alligator.
The American journal of physiology  •  1962  |  View Paper
Additional in vitro experimental support for the glucosamine hypothesis comes from findings indicating that GlcN induces insulin resistance in isolated rat muscle (23) and may modulate insulin ’s and/or glucose’s effects on pyruvate kinase (24), glycogen synthase (23, 25) and transforming growth factor-a (26).
European journal of endocrinology  •  1998  |  View Paper
Overall, the findings support a model whereby GAM promotes ER stress in retinal Müller cells, resulting in elevated REDD1 expression and thus resistance to insulin action.
Cellular signalling  •  2016  |  View Paper
For oral insulin administration via the IC-RM system, the presence of GlcN·HCl increased the hypoglycemic activity of insulin (P<0.05).
Drug design, development and therapy  •  2015  |  View Paper
RESULTS Both GlcN and ovariectomy reduced the expression of insulin , determined by the staining intensity of insulin and reverse polymerase chain reaction.
RESULTS Both GlcN and ovariectomy reduced the expression of insulin , determined by the staining intensity of insulin and reverse polymerase chain reaction.
Menopause  •  2014  |  View Paper
After 2 h glucosamine exposure in vitro, insulin release was decreased.
Islets  •  2013  |  View Paper
In neonatal rat cardiomyocytes, glucosamine treatment blocked both insulin and ET-1-stimulated glucose uptake and also eliminated the translocation of IRAP, an aminopeptidase in GLUT4-containing vesicles, from the cytoplasm to the plasma membrane.
Clinical science  •  2002  |  View Paper
CONCLUSION These data imply that glucosamine impairs glucose-induced insulin release probably through the inhibition of glucose metabolism.
Pancreas  •  2002  |  View Paper
Glucosamine not only impaired the neuroprotective effect of insulin but also induced apoptosis in R28 cells in a dose-dependent fashion.
The Journal of biological chemistry  •  2001  |  View Paper
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