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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Glucosamine and Heparin

supplement:

Glucosamine

drug:

Heparin

Research Papers that Mention the Interaction

Short-term (several days) or long-term (several weeks and months) … of cultured human diploid fibroblasts (WI-38; phase II) with heparin at 20--500 micrograms/ml inhibited cell proliferation and stimulated glycosaminoglycan … (as measured by the incorporation rates of [35S] sulfate and [14C] glucosamine into cellular … medium glycosaminoglycans).
Mechanisms of Ageing and Development  •  1980  |  View Paper
The 6-O-sulfation of glucosamine , present in higher amounts in organs that function as barriers against many foreign bodies, like lung, placenta, intestine of chicken and pig, may play an important role in this antipathogenic action of Hep.
Seminars in thrombosis and hemostasis  •  1997  |  View Paper
Heparin , in the presence of heparin-binding growth factors, also caused more than 170% stimulation of tracer glucosamine incorporation into hyaluronic acid and a 7.5-fold increase in hyaluronic acid accumulation.
In Vitro Cellular & Developmental Biology - Animal  •  1995  |  View Paper
These studies have thus demonstrated that selective N-deacetylation and N-desulfation of the glucosamine residues of heparin affect markedly both its anticoagulant activity and in vivo disposition characteristics.
The Journal of pharmacology and experimental therapeutics  •  1988  |  View Paper