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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glucosamine
drug:
Heparin
Research Papers that Mention the Interaction
“ Heparin , in the presence of heparin-binding growth factors, also caused more than 170% stimulation of tracer glucosamine incorporation into hyaluronic acid and a 7.5-fold increase in hyaluronic acid accumulation.”
Heparin and the phenotype of adult human vascular smooth muscle cells“The 6-O-sulfation of glucosamine , present in higher amounts in organs that function as barriers against many foreign bodies, like lung, placenta, intestine of chicken and pig, may play an important role in this antipathogenic action of Hep.”
“Short-term (several days) or long-term (several weeks and months) … of cultured human diploid fibroblasts (WI-38; phase II) with heparin at 20--500 micrograms/ml inhibited cell proliferation and stimulated glycosaminoglycan … (as measured by the incorporation rates of [35S] sulfate and [14C] glucosamine into cellular … medium glycosaminoglycans).”
“These studies have thus demonstrated that selective N-deacetylation and N-desulfation of the glucosamine residues of heparin affect markedly both its anticoagulant activity and in vivo disposition characteristics.”
Effects of N-deacetylation and N-desulfation of heparin on its anticoagulant activity and in vivo disposition.
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