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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Glucosamine and Glutathione

supplement:

Glucosamine

supplement:

Glutathione

Research Papers that Mention the Interaction

Glucosamine administration significantly increased intraerythrocyte total glutathione levels (from 212.…/L, P = 0.006), intraerythrocyte reduced form of glutathione (GSH) levels (from 124.7 ± 42.6 to 155.2 ± 47.7 μmol/L; P = … (GSSG) ratios (from 3.18 ± 1.64 to 3.88 ± 1.61, P = 0.04).
International heart journal  •  2017  |  View Paper
Glucose and glucosamine inhibited expression of Pax-3, a gene required for neural tube closure both in vivo and in vitro, and increased neural tube defects (NTDs) in vivo; these effects were prevented by GSH ethyl ester.
However, both glucose and glucosamine significantly decreased GSH , and increased oxidative stress, as indicated by 2',7'-dichloro-dihydrofluorescein fluorescence.
Birth defects research. Part A, Clinical and molecular teratology  •  2004  |  View Paper
GlcN also prevented the depletion of cytosolic antioxidant glutathione ( GSH ) in erythrocytes.
Environmental toxicology and pharmacology  •  2014  |  View Paper
Glutathione significantly inhibited glucosamine binding.
Experimental eye research  •  1989  |  View Paper