Possible Interaction: Glucosamine and Glucose

“… GlcN did not affect readily releasable insulin levels, glucose-stimulated … time constant of secretion, but it increased both the glucose threshold of GSIS (delta approximately 0.5-0.8 mmol/l, P < 0.03-0.… levels (delta approximately 0.3-0.5 mmol/l, P < 0.05-0.02).”

“RESULTS In each group of patients, 25 mM D-glucose significantly reduced the incorporation of [3H]glucosamine (P<0.01), but not [35S]sulphate.”

“The production of CO2 from glucosamine by intact PMNs was inhibited by glucose and dependent upon activation of the hexosemonophosphate shunt (HMPS).”

“The injection of large amounts of glucosamine into either alligators or rats increased the plasma glucose level to a height as great as that found in severe diabetes.”

“The injection of glucose combined with amounts of glucosamine which were too small to cause hyperglycemia in either animal led to the development of a very much more marked hyperglycemia than when glucose alone was injected.”

“The affinity of this uptake system for glucosamine was about 40-fold lower than that for its major substrate glucose.”

“Both glucose addition and glucose plus nitrogen amendment improved the contents of glucosamine and muramic acid significantly, but the effect varied.”

“We demonstrate that D-glucosamine inhibits the accumulation of glucose derived label and the phosphorylation of glucose by hexokinase (EC 2.7.1.1).”

“Addition of glucose to mutant cultures growing exponentially on glucosamine inhibited growth and caused death of bacteria, though chloramphenicol prevented death.”

“Growth of these mutants on glucosamine was inhibited by glucose , but growth on N-acetylglucosamine was not.”

“The inhibition of enzyme secretion by either glucosamine or 2-deoxyglucose can be completely prevented or reversed by addition of equimolar concentrations of glucose.”

“ D-Glucosamine , which is not actively transported, was inhibitory to preferential D-glucose binding as well as to the active transport of D-glucose by everted sacs of hamster jejunum.”