Possible Interaction: Glucagon and Threonine

“The …-h glucagon infusion significantly lowered the fasting levels of the glucogenic … acids aspartate (43%; P less than 0.01), threonine (46%; P less than 0.05), serine (46%; P less than 0.02), glycine (47%; P less than 0.01), and methionine (34%; P less than 0.02).”

“In these studies carried out on four subjects it has been shown that the plasma concentration of threonine , proline, glycine, alanine, lysine, arginine, citrulline, serine, cystine and histidine were very significantly lowered by catabolic doses of glucagon ( 3 4 -1 mg.”

“ Glucagon (10(-7) M) increased threonine oxidation and stimulated threonine uptake by these cells.”

“In summary, the majority of threonine oxidation occurs through the threonine dehydratase pathway in rat hepatocytes, and threonine oxidation is increased by glucagon , which also increases threonine's transport.”

“From these results, glucagon caused an increase of use of propionic acid and a decrease of use of threonine for energetic pathways in sheep liver.”

“ Glucagon caused a 76% decrease of carbon-14 threonine utilization by ovine livers, and labeled carbon dioxide production from carbon-14 threonine was only 38% of control when glucagon was infused.”

“ Glucagon directly stimulated the net hepatic uptake of alanine, glycine, glutamine, arginine, asparagine, threonine , serine, and lactate.”

“ Glucagon stimulated glucose and urea outputs in parallel fashion and stimulated the uptake and inward membrane transport of threonine at both saturating and low concentrations.”