Possible Interaction: Glucagon and Serine

“In these studies carried out on four subjects it has been shown that the plasma concentration of threonine, proline, glycine, alanine, lysine, arginine, citrulline, serine , cystine and histidine were very significantly lowered by catabolic doses of glucagon ( 3 4 -1 mg.”

“ Glucagon treatment increased serine U by 260 ± 65%versus low folate (p = 0.0004) but did not change serine P. Insulin treatment led to parallel increases in both serine P and U. Both folate cofactor availability and hormone concentrations regulate serine metabolism in the fetal liver.”

“Alanine, glycine, and serine induced a greater enhancement of both glucagon and insulin secretion than other amino acids.”

“The amino acids glycine, L-serine , L-asparagine and L-glutamine at 5 mmol/l each markedly increased glucagon release from perifused fetal lamb pancreas tissue, whereas the branched-chain amino acids L-leucine and L-valine had no effect.”

“ Glucagon directly stimulated the net hepatic uptake of alanine, glycine, glutamine, arginine, asparagine, threonine, serine , and lactate.”

“The administration of glucagon to rats causes a marked increase in the phosphorylation of a specific serine residue in lysine-rich (f1) histone of liver during a one-hour period following the administration of the hormone.”