Possible Interaction: Glucagon and Polypeptides

“Direct exposure of islets to PP inhibited glucagon release.”

“Circulating islet amyloid polypeptide binds to receptors located in the hindbrain and increases satiety, delays gastric emptying and suppresses glucagon secretion.”

“NPY and PYY, but not PP , SP, CCK or GIP, inhibited the increase in glucose release by glucagon and noradrenaline.”

“Co-expression of PP and glucagon , somatostatin or insulin was demonstrated immunohistochemically with consecutive sections, and cells with both glucagon and insulin were also observed.”

“Acute administration of glucagon to the rat in vivo inhibits hepatic polypeptide chain elongation by about 30%.”

“Glucagon secretion is stimulated by cholinergic activation, and it is known that the polypeptides VIP (vasoactive intestinal polypeptide) and GIP (gastric inhibitory polypeptide) both potentiate this cholinergically induced glucagon secretion.”

“It was confirmed that bacitracin, polypeptide antibiotics, inhibited significantly the degradation of glucagon.”

“There is a reciprocal relationship between PP and glucagon concentration in chicken pancreas.”

“ Glucagon (2.9 X 10(-7) … the phosphorylation of 15 polypeptides (by approximately 20-50%) with major phosphorylation of proteins with mol wts of 138,000, 93,000, 53,000, …,000, 35,000, 27,000 and 15,000 in intact rat islets and also stimulated insulin release by 202%.”

“The potential capability of high doses of PP to affect insulin and glucagon secretion suggests that this peptide may exert direct (paracrine) effects on the pancreatic A- and B-cells.”