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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Glucagon
supplement:
Phenylalanine
Research Papers that Mention the Interaction
“These results indicate that physiological changes in glucagon concentration modulate rat liver phenylalanine hydroxylase activity in vivo.”
Effect of glucagon on hepatic phenylalanine hydroxylase in vivo“We hypothesized that consumption of a specific combination of amino acids (arginine, alanine, and phenylalanine ; A-mix) may be involved in secretion of glucagon , and when combined with exercise may promote fat catabolism.”
“ PHE increased glucagon more than TRP or LEU, and increased insulin more than TRP.”
“ResultsOral intake of phenylalanine caused a significant increase in the concentrations of plasma glycerol and glucagon during exercise.”
“CONCLUSION In summary, ph nylalanine in an amount moderately greater than that in a large protein meal stimulates an increase in insulin and glu cagon co ncentration.”
“ Glucagon may also reduce Phe availability for protein synthesis.”
“ Glucagon stimulates in vitro liver phenylalanine (Phe) degradation, thus inducing net protein catabolism.”
“As the hypoaminoacidaemic effect of insulin and glucagon is known to be most marked for these four amino acids plus phenylalanine and tyrosine, the response of insulin and glucagon to a phenylalanine load may influence not only the fate of phenylalanine given but also the blood tyrosine level.”
“It is further demonstrated in vivo that the combined treatment with phenylalanine and glucagon results in a greater than 10-fold stimulation of BH4-dependent activity and the greatest level of 32Pi incorporation (0.75 mol of 32Pi/mol of hydroxylase subunit).”
Phenylalanine-induced phosphorylation and activation of rat hepatic phenylalanine hydroxylase in vivo.“Incubation of liver cells, in the presence of either okadaic acid or glucagon , for 15 min resulted in a significant increase in phenylalanine hydroxylase specific activity.”
“Summary Glucagon treatment for 10 days induced rat liver phenylalanine:pyruvate amino-transferase approximately eightfold but did not result in increased urinary phenylpyruvate excretion by rats administered a phenylalanine load after they had been injected with an amount of glucagon sufficient to induce the enzyme substantially.”
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