Possible Interaction: Glucagon and Methionine

“The secretion of glucagon and cortisol were slightly increased by P and M , but the plasma insulin level was not affected by beta-blockade.”

“Perfusion of 10−5 M glucagon induced a significant reduction in GPAT levels.”

“Responses appeared to involve the amiloride sensitive Na+ based reabsorptive system: responses to 10−9 M glucagon appeared to be reduced by 10−6 M amiloride, and were abolished by 10−5 M amiloride (based on 72 preparations).”

“Methanethiol … from methionine in mitochondria isolated from rat liver was increased by 50% … the rats had been given a single injection of glucagon , but was reduced by 25% when the rats had been starved for 24 …. These results indicate the physiological importance of the transaminative pathway of methionine metabolism.”

“Addition of 10−7 M glucagon to the incubation medium leads to a decreased aldrin epoxidase activity.”

“ M produced marked increases in RBF (38 +/- 4%), GFR (41 +/- 5%), and glucagon (from 23.3 +/- 3.6 to 73.3 +/- 7.1 pg/ml) over a 3-h period.”

“Both derivatives had the same maximal glucose-mobilising activity as native glucagon, but a decrease potency, suggesting a crucial role of methionine in the binding of glucagon to its hepatic receptor.”

“In the … of glucagon , the rate of incorporation of respective radioactive precursors into purine, pyrimidine, and oxidized … nucleotides was accelerated, indicating that glucagon stimulates the synthesis of PPRibP. Addition of 10−6 M colchicine, vinblastin, or podophyllotoxin abolished the glucagon or cyclic AMP-induced increase in the PPRibP level.”

“The magnitude of bovine glucagon effects were dependent on …−1 did glucagon significantly increase % GPase a. Anglerfish glucagon … 10−7 M , but had no effects at 10−9 M and 10−8 M. Scombroid and … (10−9 to 10−8 M) rather than high (10−7 M) hormone concentrations.”