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Last Updated: 2 years ago

Possible Interaction: Glucagon and Leucine

supplement:

Leucine

Research Papers that Mention the Interaction

Splanchnic removal and uptake of leucine were decreased with increased glucagon infusion.
The negative correlation between plasma glucagon and leucine levels was also significant (r=-.684).
Metabolism: clinical and experimental  •  1998  |  View Paper
Glucagon has a crucial role suppressing skeletal muscle protein synthesis by increasing l-leucine oxidation and the irreversible loss of this amino acid.
Clinical nutrition ESPEN  •  2021  |  View Paper
In summary, leucine at a dose equivalent to that present in a high-protein meal, had little effect on serum glucose or insulin concentrations but did increase the glucagon concentration.
Ingested leucine stimulated an increase in glucagon.
Leucine also attenuated the decrease in glucagon expected when glucose alone is ingested.
Metabolism: clinical and experimental  •  2008  |  View Paper
Glucagon decreased the leucine concentration (-11% +/- 3% in study 2 v study 0, P < .02) and caused a small increment in proteolysis (+6% in study 2 v study 0, P < .01) that was related to the decrement in glutamine concentrations.
Metabolism: clinical and experimental  •  1998  |  View Paper
Glucagon superinfusion caused a 63% increase in the dynamics of the process in controls (57.7 ± 11.0 L ˙ hr−1; p vs. spontaneous glucagon, p < 0.01), whereas in cirrhosis it increased on average by only 15% (26.7 ± 10.7; p = NS).
Hepatology  •  1993  |  View Paper
At a physiological concentration (0.2 mmol/liter), however, leucine was a positive stimulus for glucagon release, especially in the absence of another amino acid.
Likewise, leucine (15.0 mmol/liter) reversibly inhibited glucagon secretion evoked by glutamine in the absence of glucose.
Moreover, at a low glucose concentration (3.3 mmol/liter) and in the presence of arginine, the highest concentration of leucine (15.0 mmol/liter) provoked a sustained and reversible inhibition of glucagon release.
Thus, leucine exerted a dual effect on the secretion of glucagon , the inhibitory effect of leucine prevailing at a high concentration of the branched chain amino acid and when glucagon secretion was already stimulated by arginine or glutamine.
Endocrinology  •  1985  |  View Paper
Glucagon , caffeine and cyclic-AMP enhanced the insulinotropic effect of glucose and leucine significantly, but insulin release in response to xylitol was not affected.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  1984  |  View Paper
Concomitantly, a rise in arginase activity up to 2-fold could be measured in response to glucagon , which was largely suppressed by simultaneous presence of leucine in concentrations between 5 and 10 mM.
Experimental cell research  •  1979  |  View Paper
Ten-minute perfusions of 2, 5, and 10 mM L-leucine induced the release of glucagon and insulin in a dose-related manner.
Endocrinology  •  1978  |  View Paper
Glucagon also inhibited pancreatic secretion elicited by intraduodenal instillation of a solution of L-tryptophan and L -leucine.
Digestion  •  1974  |  View Paper
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