Possible Interaction: Glucagon and Glycine

“In normal subjects, glucagon elicited a prompt reduction in plasma amino acid levels that was greatest for alanine and glycine.”

“In these studies carried out on four subjects it has been shown that the plasma concentration of threonine, proline, glycine , alanine, lysine, arginine, citrulline, serine, cystine and histidine were very significantly lowered by catabolic doses of glucagon ( 3 4 -1 mg.”

“The rate of incorporation of C 14 from glycine into liver glycogen was increased by a previous injection of glucagon , and decreased by a previous injection of epinephrine.”

“With SEC, the decline in monomeric glucagon over time was much lower when aged in glycine (pH 10) than when aged in Tris (pH 8.5) or in citrate (pH 3).”

“Alanine, glycine , and serine induced a greater enhancement of both glucagon and insulin secretion than other amino acids.”

“ Glucagon stimulates 14CO2 production from [1-14C] glycine by isolated rat hepatocytes.”

“Addition … glucagon had no effect on the disappearance rate of Gly-… from the medium, but reduced accumulation rates of glycine (3.39 +/- 0.30 versus 1.42 +/- 30, p less than 0.01) and alanine (4.42 +/- 0.66 versus 1.35 +/- 0.39, p less than 0.01).”

“ Glucagon markedly stimulated the …, gluta' mine, and glycine , whereas dexamethasone stimulated the uptakes of both essential and non-essential amino acids only in Williams' medium E. The uptakes of … ** the amounts used for protein synthesis; the excess amounts taken up were metabolized by other pathways, such as glucose formation. *”

“Intracellular pool measurements and systematic alteration of perfusate amino acid composition indicated that the autophagic and proteolytic effects of glucagon are mediated by a hormonally induced depletion of glycine , alanine, glutamate, and glutamine; of these, glutamine alone is the most effective.”

“ Glycine infusion into post-natal lambs increases plasma glucagon.”