Possible Interaction: Glucagon and Glycerol

“… glucagon resulted in a decrease in (A-DV) non-esterified fatty acids of-0.128±0.057 mmol/l (n=…±0.036 mmol/l (n=7, p<0.05), as well as a change in deep compartment uptake of glycerol after 60 min of -0.….05), indicating increased lipolysis.”

“In human isolated adipocytes, glucagon induces a dose dependent increment of the glycerol release, which is already observed at physiological concentrations of the hormone.”

“The decrease in FFA and glycerol levels tended to be accentuated when glucagon was also infused.”

“When glucagon was added to SRIF, plasma FFA and glycerol concentrations were again increased, but to a significantly lesser extent.”

“Compared with saline treatment (n=3), coadministration of glucagon and glycerol (n=4) increased plasma glucose and insulin and decreased plasma nonesterified fatty acid concentrations in both treatment weeks, whereas glucagon alone (n=3) produced similar changes plus a decrease in plasma beta-hydroxybutyrate in the second week only.”

“We conclude that … dose of glycerol for the first 14 … potentiate the action of glucagon in the first treatment days to alleviate some symptoms of fatty liver syndrome, such as the increase … nonesterified fatty acids and the decrease in plasma glucose and insulin, in Holstein dairy cows after parturition.”

“ Glycerol administration also decreased plasma glucagon and NEFA on d 1, 7, and 13 and plasma beta-hydroxybutyrate (BHBA) on d 1 postpartum relative to the saline group.”

“This suggests that glucagon and glycerol , when co-administered, act to decrease the likelihood of metabolism-related syndrome development in dairy cows.”

“Net de novo glycogenesis (nmol substrate retained in cell glycogen.micrograms DNA-1.h-1) from propionate, lactate, and glycerol was decreased by glucagon and increased by insulin.”

“ Glucagon stimulated glycerol release from adipose tissue from FC chickens, but not from GL chickens.”

“ Glycerol ingestion induced a slight rise of plasma total glucagon.”

“They also brought about sustained rises in blood glycerol and plasma IRI, but only transiently increased the plasma IRG level.”

“ Glucagon decreased triacylglycerol synthesis only when it also lowered glycerol 3-phosphate content.”