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“ Glucagon increased cytosolic calcium concentration through the PKA-mediated phosphorylation of inositol-1,4,5-trisphosphate receptors (InsP3Rs), which associate with CRTC2.”
“ Glucagon treatment of the cell line caused a dose-dependent increase in cAMP concentration, activation of cAMP-dependent protein kinase (PKA), and transient release of intracellular calcium.”
“In addition, chelation of intracellular calcium reduced glucagon-mediated ERK1/2 activation.”
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology • 2001 | View Paper
“In fura-2 AM loaded acinar cells both INS and GLU evoked small increases in intracellular free calcium concentration [Ca2+]i compared to a much larger elevation with ACh.”