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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Glucagon
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Calcium appears to inhibit octreotide suppression of glucagon and insulin secretion in patients with glucagonoma and insulinoma, respectively.”
Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma.“Finally, calcium mediates cellular responses to glucagon stimulation (3,4) and thus affects the hepatic glucose output.”
“ Glucagon treatment of the cell line caused a dose-dependent increase in cAMP concentration, activation of cAMP-dependent protein kinase (PKA), and transient release of intracellular calcium.”
“In addition, chelation of intracellular calcium reduced glucagon-mediated ERK1/2 activation.”
“Intravenous application of 1 mg glucagon causes a significant decrease of the magnesium, calcium , and phosphate concentrations in the serum.”
“SummaryPrevious work by this and other laboratories has shown that glucagon administration stimulates calcium uptake by subsequently isolated hepatic mitochondria.”
The effect of glucagon on the kinetics of hepatic mitochondrial calcium uptake“ Ca++ is therefore an essential requirement for the normal secretory process of pancreatic glucagon , possibly involving uptake and accumulation within the A cell, as established for the B cell.”
“At 0.25 mmol/l of calcium , basal secretory rates of glucagon were elevated and a small stimulatory effect of glibenclamide was seen.”
“The Ca and Mg reabsorptive capacity of the distal segment was increased by glucagon and by PTH.”
“ Glucagon stimulated gluconeogenesis from lactate in duckling liver and the stimulation was 2.2-fold higher in CA than in TN fasted birds.”
“In frogs, however, the effect of glucagon on I Ca was smaller and occurred at a concentration tenfold lower than in rats, and adenylyl cyclase was not modified.”
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