Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma.

 appears to inhibit octreotide suppression of 

 and insulin secretion in patients with glucagonoma and insulinoma, respectively.

Influence of verapamil on glucose tolerance.

 (3,4) and thus affects the hepatic glucose output.

[The effect of glucagon on serum electrolyte concentrations in man].

 causes a significant decrease of the magnesium, 

, and phosphate concentrations in the serum.

A glucagon fragment is responsible for the inhibition of the liver Ca2+ pump by glucagon

 in liver plasma membranes independently of adenylate cyclase activation1.

InsP3 Receptor Regulates Hepatic Gluconeogenesis in Fasting and Diabetes

 concentration through the PKA-mediated phosphorylation of inositol-1,4,5-trisphosphate receptors (InsP3Rs), which associate with CRTC2.

Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase.

 treatment of the cell line caused a dose-dependent increase in cAMP concentration, activation of cAMP-dependent protein kinase (PKA), and transient release of intracellular 

Increased Lipolysis and Energy Expenditure in a Mouse Model with Severely Impaired Glucagon Secretion

Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans.

Effect of cold-acclimation on oxygen uptake and glucose production of perfused duckling liver.

 stimulated gluconeogenesis from lactate in duckling liver and the stimulation was 2.2-fold higher in 

Interactions of Islet Hormones with Acetylcholine in the Isolated Rat Pancreas

In fura-2 AM loaded acinar cells both INS and

 evoked small increases in intracellular free 

 concentration [Ca2+]i compared to a much larger elevation with ACh.

Effects of glucagon on serum calcium, magnesium and strontium levels in rats.

The results show significant decreases in serum

 administration, and in daily administration the effect peaks on the 3rd day and returns to baseline values by the 9th day.

Glucagon inhibits water and NaCl transports in the proximal convoluted tubule of the rat kidney

In the loop, besides its previously described stimulatory effects on Na+, Cl−, K+,

 strongly inhibited Pi reabsorption, very probably in the proximal straight tubule.

Calcitonin secretion and cyclic AMP-efflux from C-cells, stimulated by glucagon and either calcium or Bay K 8644.

 or Bay K 8644 resulted in an additive effect.

 or Bay K 8644 caused a reduction of the cAMP-increase obtained by glucagon alone.

Effects of glucagon on Na+, Cl−, K+, Mg2+ and Ca2+ transports in cortical and medullary thick ascending limbs of mouse kidney

 and Mg2+∶JNa+ increased from 204±20 to 228±23 pmol · min−1 · mm−1,JCl− from 203±18 to 234±21 pmol · min−….08 pmol · min−1 · mm−1.JK+ remained unchanged: 3.2±1.3 versus 4.0±1.9 pmol · min−1 · mm−1.

Evidence of cyclic AMP-independent action of glucagon on calcium mobilization in rat hepatocytes.

 concentration as measured by aequorin bioluminescence.

It has been proposed by Wakelam et al. (Nature 323 (1986) 68-71) that low concentrations of

 from an intracellular pool by causing polyphosphoinositide breakdown.

Modulation of glucagon effects by changes in extracellular pH and calcium.

In isolated hepatocytes, the stimulation … phosphorylase alpha activity by

 concentrations lower than 0.2 mM. This suggests that, although glucagon action is chiefly cAMP-mediated, its effect on calcium mobilization (affecting various cellular process, including cAMP production itself) should also be taken into account.

Sources of calcium mobilized by glucagon in isolated rat hepatocytes.

 from both intracellular and extracellular pools and that the intracellular calcium pool involved in glucagon action may be different from that mobilized by either phenylephrine or angiotensin II.

The role of calcium and phospholipase A2 in glucagon-induced enhancement of mitochondrial calcium retention.

 from non-mitochondrial stores in hepatocytes, presumably by activation of the phosphoinositide-specific phospholipase C (2,3).

Treatment of intact hepatocytes with the calcium ionophore A23187 perturbs both the synthesis and the degradation of the second messenger cyclic AMP. Actions on adenylate cyclase and cyclic AMP phosphodiesterase activities.

 ability to elevate intracellular cyclic AMP concentrations in intact hepatocytes.

The actions of arginine and glucose on glucagon secretion are mediated by opposite effects on cytoplasmic Ca2+.

Characterization of responses of isolated rat hepatocytes to ATP and ADP.

 in response to ATP or ADP can be potentiated by low concentrations of 

Stimulation by glucagon and PTH of Ca and Mg reabsorption in the superficial distal tubule of the rat kidney

 and Mg reabsorptive capacity of the distal segment was increased by 

Regulation of hepatic glycogenolysis by glucagon in male and female rats. Role of cAMP and Ca2+ and interactions between epinephrine and glucagon.

At supra-physiologic concentrations (and in the male only),

 slightly increased the cytosolic free calcium, the fractional efflux of 

, and, after 2 h, decreased the cell calcium content.

Difference in calcium dependency of insulin, glucagon and somatostatin secretion in response to glibenclamide in perfused rat pancreas

 were elevated and a small stimulatory effect of glibenclamide was seen.

Effect of glucagon on amino acid transport and cyclic adenosine 3':5'-monophosphate production in rat hepatoma cell line McA-RH 8994 in culture.

We have reported previously that, in monolayer cultures of rat hepatocytes,

 of AIB transport while it markedly inhibited the production of cAMP in response to glucagon.

Inhibition by calcium channel blockers of the glycogenolytic effect of glucagon in perfused rat liver.

 also at a step (or steps) subsequent to cyclic AMP production and before the activation of phosphorylase b, … by inhibiting glucagon-induced mobilization of calcium from intracellular calcium pools rather than inhibiting calcium influx into hepatocytes.

Calcium deprivation enhances glucagon release in the presence of 2-ketoisocaproate.

The results are interpreted in support of the hypothesis that

 may play an inhibitory role in the control of 

Somatostatin elaboration by monolayer cell cultures derived from transplantable rat medullary thyroid carcinoma: synergistic stimulatory effects of glucagon and calcium.

Calcium-dependent hormonal regulation of amino acid transport and cyclic AMP accumulation in rat hepatocyte monolayer cultures.

 markedly enhanced the stimulation of AIB transport in cultures treated with 

, catecholamines, and dexamethasone plus glucagon.

However, in calcium-restored cultures, increasing the

 concentration of the medium resulted in increased stimulation of AIB transport and decreased production of cyclic AMP by 

Glucagon-induced Hypocalcemia in the Rat: Effects of Maturation and Insulin

 concentration in a variety of mammals including man (2, 6–9, 11), but no studies of this phenomenon in the neonatal period have been reported.

A possible role of calcium in the action of glucagon, cAMP and dibutyryl cAMP on the metabolism of free fatty acids by rat hepatocytes.

Basal rates of triacylglycerol synthesis, ketogenesis, and output of glucose, and the responses to

 and the cyclic nucleotides were diminished by depletion of 

 plays an important role in hepatic triacylglycerol synthesis and in ketogenesis and on the actions of 

 and adenylic cyclic nucleotides on these metabolic pathways.

Effects of glucagon, insulin and cyclic-AMP on mitochondrial calcium uptake in the liver.

 uptake both in vivo and in the perfused liver.

Effect of Verapamil on pancreatic glucagon release from the isolated, perfused canine pancreas.

The results are compatible with earlier findings from our laboratory demonstrating that

 plays a key role in the stimulus-secretion coupling of 

Paradoxical effects of calcium-glucagon interaction on cardiac muscle contractility of isolated guinea pig atria.

It is hypothesized that since glucagon does not activate c-AMP in this tissue then the combined action of high

 leads to degeneration of contractility; with Isuprel and high calcium, atrial contractility is maintained via Isuprel's c-AMP activation.

Interaction of calcium and glucose on glucagon secretion.

With 150 mg/dl glucose, addition of the normally stimulating 0.5 mEq/l

 caused abrupt and complete inhibition of 

 secretion, and this persisted at all higher calcium concentrations.

Studies on the role of cyclic guanosine 3':5'-monophosphate and extracellular Ca2+ in the regulation of glycogenolysis in rat liver cells.

 and catecholamines was only slightly inhibited by the omission of 

 inhibited the rise in adenylate cyclase activity of lysed rat liver cells due to 

 or isoproterenol but not that due to fluoride.

The role of calcium in glucagon release, interactions between glucose and calcium

 plays, at least, a dual role — both inhibitory and 

 secretion, but the intimate mechanisms by which calcium exerts such a dual action are at present unknown.

The role of calcium in glucagon release. Interactions between arginine and calcium.

Taking into account this, as well as other data presently available in the literature, it is suggested that

 plays a versatile role - permissive, inhibitory and stimulatory - in 

The effect of calcium and magnesium on glucagon secretion.

Calcium ions and the cardiotonic action of glucagon (calcium fluxes-myocardial function-asystole-membrane transport-cat).

 may influence intracellular movement of 

, even when its transmembrane movement is affected only slightly.

Hormone-calcium interactions with the plasma membrane of rat liver cells.

In the concentration range of 10(-6) to 10(-8) molar,

, epinephrine, and hydro-cortisone increased 

 binding to the plasma membrane, whereas insulin decreased this binding.

The effect of glucagon on calcium exchangeability, coronary blood flow, myocardial function and high energy phosphate stores.

These results have been interpreted to mean that

 which is accumulated by heart muscle during excitation, and that this accumulation may result from the effect of glucagon on the adenyl cyclase enzyme.

Glucagon-induced hypocalcemia.

 is also known to lower serum phosphate and to enhance the urinary excretion of 

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Possible Interaction: Glucagon and Calcium Supplement

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Research Papers that Mention the Interaction