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Discover Supplement-Drug Interactions
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Last Updated: 4 months ago
drug:
Glucagon
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Calcium appears to inhibit octreotide suppression of glucagon and insulin secretion in patients with glucagonoma and insulinoma, respectively.”
Calcium reverses octreotide inhibition of insulin and glucagon levels in patients with insulinoma and glucagonoma.“Finally, calcium mediates cellular responses to glucagon stimulation (3,4) and thus affects the hepatic glucose output.”
“Intravenous application of 1 mg glucagon causes a significant decrease of the magnesium, calcium , and phosphate concentrations in the serum.”
“ Glucagon increased cytosolic calcium concentration through the PKA-mediated phosphorylation of inositol-1,4,5-trisphosphate receptors (InsP3Rs), which associate with CRTC2.”
“ Glucagon treatment of the cell line caused a dose-dependent increase in cAMP concentration, activation of cAMP-dependent protein kinase (PKA), and transient release of intracellular calcium.”
“In addition, chelation of intracellular calcium reduced glucagon-mediated ERK1/2 activation.”
“BACKGROUND Secretion of insulin and glucagon is triggered by elevated intracellular calcium levels.”
Increased Lipolysis and Energy Expenditure in a Mouse Model with Severely Impaired Glucagon Secretion“…),glucagon (…−, Ca2+ and Mg2+∶JNa+ increased from 204±20 to 228±23 pmol · min−1 · mm−1,JCl− from 203±18 to 234±21 pmol · min−….08 pmol · min−1 · mm−1.JK+ remained unchanged: 3.2±1.3 versus 4.0±1.9 pmol · min−1 · mm−1.”
“Chelation of intracellular calcium (intracellular [Ca(2+)]) reduced glucagon-mediated ERK1/2 activation.”
“ Glucagon stimulated gluconeogenesis from lactate in duckling liver and the stimulation was 2.2-fold higher in CA than in TN fasted birds.”
“In fura-2 AM loaded acinar cells both INS and GLU evoked small increases in intracellular free calcium concentration [Ca2+]i compared to a much larger elevation with ACh.”
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