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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Glucagon
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“A 30-min infusion of OAK (20 g/m2) induced significant increases in insulin levels (from 15 through 60 min) and in glucagon levels (from 15 through 90 min).”
The effect of ornithine-alpha-ketoglutarate on insulin and glucagon secretion in normal subjects.“The cytosolic concentration of 2-oxoglutarate is known to fall precipitously under the influence of glucagon and other hormones that stimulate gluconeogenesis, and it is suggested that the hormone-induced decrease in 2-oxoglutarate content would alleviate the inhibition of phosphoenolpyruvate carboxykinase and stimulate flux from oxaloacetate to phosphoenolpyruvate.”
Physiological concentrations of 2-oxoglutarate regulate the activity of phosphoenolpyruvate carboxykinase in liver.“This correlation holds also when oxoglutarate production from glutamine or proline is increased by ammonium ions or glucagon.”
“With respect to the utilization of pyruvate, 2-oxoglutarate and glutamate, glucagon produced a significant effect within 1 min.”
“With respect to the regulation of gluconeogenesis the observation is of special interest that glucagon markedly lowered the levels of 2-oxoglutarate and glutamate in the perfused liver [14,15] , and in the cytosolic and mitochondrial compartments of isolated liver cells [ 121.”
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