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Possible Interaction: Glucagon and Alpha-Ketoglutarate

Research Papers that Mention the Interaction

Finally, OKG increased insulinemia and glucagonemia (mean: +24% at 15 min, p less than 0.05 and +30% at 60 min, p less than 0.01, respectively).
Journal of the American College of Nutrition  •  1990  |  View Paper
A 30-min infusion of OAK (20 g/m2) induced significant increases in insulin levels (from 15 through 60 min) and in glucagon levels (from 15 through 90 min).
Acta endocrinologica  •  1981  |  View Paper
The cytosolic concentration of 2-oxoglutarate is known to fall precipitously under the influence of glucagon and other hormones that stimulate gluconeogenesis, and it is suggested that the hormone-induced decrease in 2-oxoglutarate content would alleviate the inhibition of phosphoenolpyruvate carboxykinase and stimulate flux from oxaloacetate to phosphoenolpyruvate.
The Biochemical journal  •  1992  |  View Paper
With respect to the utilization of pyruvate, 2-oxoglutarate and glutamate, glucagon produced a significant effect within 1 min.
European journal of biochemistry  •  1980  |  View Paper
With respect to the regulation of gluconeogenesis the observation is of special interest that glucagon markedly lowered the levels of 2-oxoglutarate and glutamate in the perfused liver [14,15] , and in the cytosolic and mitochondrial compartments of isolated liver cells [ 121.
FEBS letters  •  1978  |  View Paper
After glucagon treatment, cytosolic pyruvate is decreased by 37%, whereas glutamate and 2-oxoglutarate decrease by 70%.
The Biochemical journal  •  1977  |  View Paper
In livers perfused with H14CO3 for 1 min, glucagon decreased the radioactivities of oxalacetate, malate, citrate, and α-ketoglutarate and increased those of aspartate, P-pyruvate, succinate, and fumarate.
The changes induced by glucagon indicated stimulation of aspartate and P-pyruvate formation from oxalacetate and of succinate formation from α-ketoglutarate.
The Journal of biological chemistry  •  1973  |  View Paper