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Last Updated: 2 years ago

Possible Interaction: Glucagon and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

Glucagon stimulation provoked a substantial rise in cortisol and adrenocorticotropin ( ACTH ) that was independent of gender, age, or underlying growth hormone deficiency.
Journal of pediatric endocrinology & metabolism : JPEM  •  2005  |  View Paper
Glucagon is known to induce a clear increase of GH, ACTH and cortisol levels in humans, at least after intramuscular administration.
Clinical endocrinology  •  2004  |  View Paper
It is widely accepted that glucagon stimulates GH, ACTH and cortisol release in humans, though the mechanisms underlying these effects are unclear.
Pituitary  •  2004  |  View Paper
In conclusion, this study demonstrates that in obese patients the im administration of glucagon elicits blunted GH response but exaggerated ACTH increase which is uncoupled with the adrenal response.
glucagon administration induced clear increase in GH (peak vs baseline, mean±SE: 11.6±….4 vs 3.3±0.7 μg/l, p<0.02), and ACTH (52.9±15.2 vs 19.0±1.5 pg/ml, …<0.02) levels which peaked at +150 and +165 min, respectively.
Journal of endocrinological investigation  •  2002  |  View Paper
Taken together, these findings suggest that glucagon , through the activation of unidentified receptors located on ZF/R cells, inhibits adenylate cyclase, thereby dampening glucocorticoid response to ACTH.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  2000  |  View Paper
This study demonstrates that the intramuscluar administration of glucagon (4 mg) provids a potent stimulus to ACTH and cortisol secretion in healthy subjects.
The Journal of clinical endocrinology and metabolism  •  1976  |  View Paper
Glucagon and GLP-1 (10(-7) M) decreased by about 45-50% cyclic-AMP production by dispersed inner adrenocortical cells in response to ACTH (10(-9) M), but not to the adenylate cyclase activator forskolin (10(-5) M).
In light of …: (i) glucagon and GLP-1, via the … of rat adrenal cortex to ACTH ; and (ii) the mechanism underlying the effect of glucagon and GLP-1 is probably two-fold, and … ACTH-induced activation of adenylate cyclase and the impairment of the late steps of glucocorticoid synthesis.
Life sciences  •  1999  |  View Paper
It is postulated that glucagon may inhibit ACTH secretion either by a direct effect on the hypothalamus or indirectly through insulin, which is known to stimulate endogenous somatostatin release.
The Journal of endocrinology  •  1995  |  View Paper
glucagon by microsomal membranes include: (a) peptide hormones of … little or no tertiary structure, such as adrenocorticotropic hormone ; (b) peptide antibiotics, such as bacitracin; (c) bile salts and synthetic detergents, such as sodium deoxycholate …) polyene antibiotics, such as filipin; and (e) metal-complexing agents, such as 1,10-phenantroline.
Biochimica et biophysica acta  •  1974  |  View Paper
Significant increases of corticosteroids were found in all experiments after ACTH or insulin but a significant decrease was observed 1 h after glucagon administration.
Hormone research  •  1973  |  View Paper
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